The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila
The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila
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DOI：
10.1016/s0092-8674(00)81036-3
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发表时间：
1996-02-23
期刊：
影响因子：
64.5
通讯作者：
Saito, H
中科院分区：
文献类型：
--
作者：
Krueger, NX;VanVactor, D;Saito, H
DLAR是果蝇体内一种类似受体的跨膜蛋白酪氨酸磷酸酶，几乎只由发育中的神经元表达。对DLAR功能缺失突变的分析表明，DLAR在运动神经元生长锥引导过程中起着关键作用。节段性神经b(SNB)运动轴突通常离开共同的运动通路，进入腹侧靶区，然后在特定的腹侧肌肉上突触。在DLAR突变胚胎中，SNB轴突绕过它们正常的靶区，继续沿着共同的路径延伸。SND运动神经元也会出现寻路错误，而SNA和SNC轴突看起来正常。因此，DLAR控制着某些运动轴突在发育中的果蝇神经系统中导航特定选择点的能力。
DLAR is a receptor-like, transmembrane protein-tyrosine phosphatase in Drosophila that is expressed almost exclusively by developing neurons. Analysis of Dlar loss-of-function mutations shows that DLAR plays a key role during motoneuron growth cone guidance. Segmental nerve b (SNb) motor axons normally exit the common motor pathway, enter the ventral target region, and then synapse on specific ventral muscles. In Dlar mutant embryos, SNb axons bypass their normal target region and instead continue to extend along the common pathway. SNd motor axons also make pathfinding errors, while SNa and SNc axons appear normal. Thus, DLAR controls the ability of certain motor axons to navigate specific choice points in the developing Drosophila nervous system.