A stereological study of glomerular number and volume: Preliminary findings in a multiracial study of kidneys at autopsy
A stereological study of glomerular number and volume: Preliminary findings in a multiracial study of kidneys at autopsy
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DOI：
10.1046/j.1523-1755.63.s83.8.x
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发表时间：
2003-02-01
影响因子：
19.6
通讯作者：
Bertram, JF
中科院分区：
文献类型：
--
作者：
Hoy, WE;Douglas-Denton, RN;Bertram, JF
背景。本报告描述了一项研究的初步结果，肾小球的数量和体积及其相关性，在人的肾脏进行尸检。尸检时称量双肾，右肾灌注固定并亚采样，使用物理检测器/分配器组合进行肾小球总数和平均肾小体体积的体视学估计。迄今为止研究的78个肾脏来自澳大利亚土著居民、澳大利亚非土著居民、美国黑人和美国白人，年龄从新生儿到84岁不等。肾小球数量几乎是9倍（从210,332到1,825,380），平均（SD）为784,909 (314,686)；在整个成年期下降（r=-0.32， P=0.009）。成人平均肾小体体积变化5.6倍，与肾小球数量呈负相关（r=-0.38， P=0.001）。成人的总肾小体体积变化了15.8倍。各年龄段肾脏重量与体表面积（BSA）相关(r=0.76， P
Background. This report describes preliminary results of a study of glomerular number and volume and their associations, in kidneys of people coming to autopsy.Methods. Both kidneys were weighed at autopsy and the right kidney was perfusion-fixed and sub-sampled for stereological estimation of total glomerular number, and of mean renal corpuscle volume, using the physical disector/fractionator combination.Results. The 78 kidneys studied so far were from Australian Aborigines, Australian non-Aborigines, US blacks and US whites, ages newborn to 84 years. Glomerular number ranged almost ninefold (from 210,332 to 1,825,380), with mean (SD) of 784,909 (314,686); it decreased throughout adult life (r=-0.32, P=0.009). Mean renal corpuscle volume varied 5.6-fold in adults and was inversely correlated with glomerular number (r=-0.38, P=0.001). Total renal corpuscle volume varied in adults by a factor of 15.8. Kidney weight correlated with body surface area (BSA) at all ages (r=0.76, P