Diagnosis of cystic echinococcosis, central Peruvian Highlands.
Diagnosis of cystic echinococcosis, central Peruvian Highlands.
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DOI：
10.3201/eid1402.061101
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发表时间：
2008-02
影响因子：
11.8
通讯作者：
Gilman RH
中科院分区：
文献类型：
--
作者：
Gavidia CM;Gonzalez AE;Zhang W;McManus DP;Lopera L;Ninaquispe B;Garcia HH;Rodríguez S;Verastegui M;Calderon C;Pan WK;Gilman RH
尽管血清学检测在现场的实用性有限，但超声检查、X线摄影以及两种血清学检测均证实了高患病率。
我们通过四种诊断方法评估了秘鲁中部高原地区囊型包虫病（CE）的患病率：对949人进行超声检查，对829人进行X线摄影，对929人进行两种血清学检测（使用牛棘球蚴囊液[IBCF]和重组EpC1谷胱甘肽S - 转移酶[rEpC1 - GST]抗原的两种免疫印迹形式）。对于IBCF和rEpC1 - GST检测，肝脏和肺部CE的患病率分别为4.7%和1.1%，血清阳性率分别为8.9%和19.7%。IBCF和rEpC1 - GST检测的血清阳性结果频率分别为：所有肝囊肿为35.7%和16.7%，排除肝钙化后为47.1%和29.4%，肺囊肿为22.2%和33.3%。针对肺囊肿、钙化囊肿、小囊肿以及肺和肝以外部位囊肿的免疫反应较弱，这可能解释了血清学诊断检测效果不佳的原因。我们证实CE在秘鲁是高度流行的，并强调现有血清学检测在现场的效果有限。
High prevalence was confirmed by ultrasonography, radiography, and 2 serologic tests, although usefulness of serologic testing in the field was limited. We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively. Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively. Weak immune response against lung cysts, calcified cysts, small cysts, and cysts in sites other than lung and liver might explain the poor performance of the serodiagnostic tests. We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field.
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影响因子：
2.4
作者：
Macpherson, CNL;Bartholomot, B;Frider, B
通讯作者：
Frider, B
影响因子：
1.9
作者：
Dendukuri, N;Joseph, L
通讯作者：
Joseph, L
影响因子：
6.4
作者：
Li, J;Zhang, WB;McManus, DP
通讯作者：
McManus, DP
影响因子：
2
作者：
Black, MA;Craig, BA
通讯作者：
Craig, BA
影响因子：
4
作者：
LIGHTOWLERS, MW
通讯作者：
LIGHTOWLERS, MW