Hypoxia-inducible factors in T lymphocyte differentiation and function. A Review in the Theme: Cellular Responses to Hypoxia.
Hypoxia-inducible factors in T lymphocyte differentiation and function. A Review in the Theme: Cellular Responses to Hypoxia.
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DOI：
10.1152/ajpcell.00204.2015
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发表时间：
2015-11
期刊：
影响因子：
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通讯作者：
Jin-Hui Tao;J. Barbi;F. Pan
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文献类型：
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作者：
Jin-Hui Tao;J. Barbi;F. Pan
低氧浓度或缺氧是发炎组织的共同特征。因此，这并不奇怪，主要由缺氧诱导因子（HIF）控制的缺氧应激反应途径与免疫细胞的正常功能高度相关。HIF在免疫细胞中的表达和稳定不仅可以由缺氧触发，还可以由与白细胞活化和炎症相关的各种刺激和病理应激触发。除了作为氧缺乏传感器的作用外，HIF也是免疫细胞代谢功能的主要调节剂。在阐明HIF在先天性和适应性免疫的各个方面所发挥的作用方面正在取得快速进展。在这里，我们讨论了一些突破，揭示了HIF表达和活性如何影响不同T细胞群的分化和功能。从这些发现中获得的见解可以作为未来旨在微调免疫反应的疗法的基础。
Low oxygen concentrations or hypoxia is a trait common to inflamed tissues. Therefore it is not surprising that pathways of hypoxic stress response, largely governed by hypoxia-inducible factors (HIF), are highly relevant to the proper function of immune cells. HIF expression and stabilization in immune cells can be triggered not only by hypoxia, but also by a variety of stimuli and pathological stresses associated with leukocyte activation and inflammation. In addition to its role as a sensor of oxygen scarcity, HIF is also a major regulator of immune cell metabolic function. Rapid progress is being made in elucidating the roles played by HIF in diverse aspects of both innate and adaptive immunity. Here we discuss a number of breakthroughs that have shed light on how HIF expression and activity impact the differentiation and function of diverse T cell populations. The insights gained from these findings may serve as the foundation for future therapies aimed at fine-tuning the immune response.