Leptin resistance and diet-induced obesity: central and peripheral actions of leptin
Leptin resistance and diet-induced obesity: central and peripheral actions of leptin
复制标题
DOI：
10.1016/j.metabol.2014.10.015
复制
发表时间：
2015-01-01
影响因子：
9.8
通讯作者：
Alfredo Martinez, Jose
中科院分区：
文献类型：
--
作者：
Sainz, Neira;Barrenetxe, Jaione;Alfredo Martinez, Jose
肥胖是一种慢性疾病，是全球最严重的健康负担之一，与能量摄入和消耗之间的不平衡（受环境和基因相互作用调节）导致的体脂过剩有关。脂肪来源的激素瘦素通过大脑中的一个特定受体来调节能量平衡和体重，尽管这种蛋白质也可以在周围组织中引发无数的行为。肥胖的人，而不是瘦素缺乏，在大多数情况下，有高水平的循环瘦素。这些高水平的激素无法控制体重，这表明存在对激素的抵抗过程，这可能是体重调节受到干扰的部分原因。此外，瘦素抵抗会损害瘦素的生理外周功能，如脂质和碳水化合物代谢以及肠道营养利用。本文总结了这些关于瘦素抵抗发展的发现，以及这种激素在肥胖状态的发展和维持中的作用。因此，我们关注瘦素作用受损对脂肪组织、肝脏、骨骼肌和肠道功能的影响及其与饮食性肥胖的相关关系。一些炎症介质参与肥胖的发展及其在瘦素抵抗发展中的作用也进行了讨论。(C) 2015爱思唯尔公司版权所有。
Obesity is a chronic disease that represents one of the most serious global health burdens associated to an excess of body fat resulting from an imbalance between energy intake and expenditure, which is regulated by environmental and genetic interactions. The adipose-derived hormone leptin acts via a specific receptor in the brain to regulate energy balance and body weight, although this protein can also elicit a myriad of actions in peripheral tissues.Obese individuals, rather than be leptin deficient, have in most cases, high levels of circulating leptin. The failure of these high levels to control body weight suggests the presence of a resistance process to the hormone that could be partly responsible of disturbances on body weight regulation. Furthermore, leptin resistance can impair physiological peripheral functions of leptin such as lipid and carbohydrate metabolism and nutrient intestinal utilization.The present document summarizes those findings regarding leptin resistance development and the role of this hormone in the development and maintenance of an obese state. Thus, we focused on the effect of the impaired leptin action on adipose tissue, liver, skeletal muscle and intestinal function and the accompanying relationships with diet-induced obesity. The involvement of some inflammatory mediators implicated in the development of obesity and their roles in leptin resistance development are also discussed. (C) 2015 Elsevier Inc. All rights reserved.