Endothelial function and endothelial nitric oxide synthase intron 4a/b polymorphism in primary hyperparathyroidism
Endothelial function and endothelial nitric oxide synthase intron 4a/b polymorphism in primary hyperparathyroidism
复制标题
DOI：
10.3275/6400
复制
发表时间：
2009-07-01
影响因子：
5.4
通讯作者：
Erbil, Y.
中科院分区：
文献类型：
--
作者：
Ekmekci, A.;Abaci, N.;Erbil, Y.
背景和目的：有症状的原发性甲状旁腺功能亢进（pHT）患者的心血管发病率和死亡率增加。内皮型一氧化氮合酶（eNOS）内含子4a/B多态性与不同人群冠心病和高血压相关。我们的目的是评估pHT患者术前高钙和术后正常钙期间的内皮功能，并确定eNOS基因内含子4a/B多态性是否影响内皮功能。主题和方法：对40例pHT患者（年龄48.48 ± 11.64岁）进行术前检查，并在甲状旁腺切除术后5.8 ± 1.9个月进行复查。43名健康志愿者（年龄47.13 ± 8.14岁）作为对照组。通过肱动脉血流介导的舒张功能（FMD）测定内皮功能。聚合酶链反应检测eNOS 4 a/B多态性。结果：与对照组相比，患者术前FMD显著降低（8.48 ± 1.78% vs 19.49 ± 2.34%，p
Background and aim: Patients with symptomatic primary hyperparathyroidism (pHT) have increased cardiovascular morbidity and mortality. Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with coronary artery disease and hypertension in various populations. Our aim is to evaluate endothelial function in patients with pHT during pre-operative hypercalcemic and postoperative normocalcemic periods and to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function. Subjects and Methods: Forty patients with pHT (age 48.48 +/- 11.64 yr) were examined pre-operatively and re-examined 5.8 +/- 1.9 months after parathyroidectomy. Forty-three healthy subjects (age 47.13 +/- 8.14 yr) were served as control group. Endothelial function was determined by flow-mediated dilation of brachial artery (FMD). eNOS4a/b polymorphism was detected by polymerase chain reaction. Results: FMD was significantly lower in patients pre-operatively compared with controls (8.48 +/- 1.78% vs 19.49 +/- 2.34%, p