Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder
Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder
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DOI：
10.1016/j.biopsych.2007.07.009
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发表时间：
2008-03-15
影响因子：
10.6
通讯作者：
Knudsen, Gitte M.
中科院分区：
文献类型：
--
作者：
Frokjaer, Vibe G.;Mortensen, Erik L.;Knudsen, Gitte M.
背景：5-羟色胺能功能障碍与情感性精神障碍有关。高特质神经质，如人格量表所测量的，是重度抑郁症的危险因素。在这项研究中，我们调查是否神经质与5-羟色胺2A受体结合在大脑区域的相关affective disorders.Methods：83名健康志愿者完成了标准化的人格问卷NEO-PI-R（修订的NEO人格量表），并进行了[F-18]阿坦色林正电子发射断层扫描成像评估5-羟色胺2A受体结合。神经质得分和额缘5-羟色胺2A受体结合之间的相关性通过多元线性回归分析进行评估，调整年龄和gender.Results：神经质与额缘5-羟色胺2A受体结合呈正相关[r（79）= .24，p = .028]。对神经质的六个组成特征的贡献进行的事后分析表明，这种相关性主要是由其中两个特征驱动的：脆弱性和焦虑。事实上，脆弱性，定义为一个人的困难，在应对压力，表现出最强的正相关性，这仍然显着校正后的多重比较（r = .35，p = .009）。结论：在健康受试者的人格维度神经质，特别是其组成特征，脆弱性，与额缘5-羟色胺2A结合呈正相关。我们的研究结果指出，情感障碍的人格风险因素和多巴胺能递质系统之间的神经生物学联系，并确定5-羟色胺2A受体作为情感障碍易感性的生物标志物。
Background: Serotonergic dysfunction has been associated with affective disorders. High trait neuroticism, as measured on personality inventories, is a risk factor for major depression. In this study we investigated whether neuroticism is associated with serotonin 2A receptor binding in brain regions of relevance for affective disorders.Methods: Eighty-three healthy volunteers completed the standardized personality questionnaire NEO-PI-R (Revised NEO Personality Inventory) and underwent [F-18]altanserin positron emission tomography imaging for assessment of serotonin 2A receptor binding. The correlation between the neuroticism score and frontolimbic serotonin 2A receptor binding was evaluated by multiple linear regression analysis with adjustment for age and gender.Results: Neuroticism correlated positively with frontolimbic serotonin 2A receptor binding [r(79) = .24, p = .028]. Post hoc analysis of the contributions from the six constituent traits of neuroticism showed that the correlation was primarily driven by two of them: vulnerability and anxiety. Indeed, vulnerability, defined as a person's difficulties in coping with stress, displayed the strongest positive correlation, which remained significant after correction for multiple comparisons (r = .35, p = .009).Conclusions: In healthy subjects the personality dimension neuroticism and particularly its constituent trait, vulnerability, are positively associated with frontolimbic serotonin 2A binding. Our findings point to a neurobiological link between personality risk factors for affective disorder and the serotonergic transmitter system and identify the serotonin 2A receptor as a biomarker for vulnerability to affective disorder.