Exercise during pregnancy protects adult mouse offspring from diet-induced obesity.
Exercise during pregnancy protects adult mouse offspring from diet-induced obesity.
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DOI：
10.1186/s12986-015-0052-z
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发表时间：
2015
影响因子：
4.5
通讯作者：
Araujo RC
中科院分区：
文献类型：
--
作者：
Wasinski F;Bacurau RF;Estrela GR;Klempin F;Arakaki AM;Batista RO;Mafra FF;do Nascimento LF;Hiyane MI;Velloso LA;Câmara NO;Araujo RC
体育锻炼诱导参与肥胖代谢的基因表达的积极变化。母亲的锻炼在后代出生后不久就引起了适应。在这里，我们调查是否成年小鼠后代的游泳训练的母亲是保护免受发展的有害影响的高脂肪饮食（HFD）。我们的研究包括两个部分。首先，将雌性C57 BL/6小鼠分为一个久坐组和一个游泳训练组（妊娠前和妊娠期间，n = 18）。在第二部分中，成年后代（n = 12）的训练和久坐的母亲被挑战HFD 16周。值得注意的是，大多数分析是在雄性后代中进行的。我们的研究结果表明，母体运动对小鼠后代有几个有益的影响，并保护他们免受HFD在成年后的有害影响。具体来说，在怀孕期间游泳会导致2个月大的后代出生体重较低。在成年期进行4个月的HFD，我们的研究提供了新的数据，男性后代的代谢训练的母亲。与久坐不动的母亲的后代相比，后代的体重增加较少，伴随着较少的体脂，他们在白天消耗更多的卡路里。此外，我们观察到骨骼肌中脂联素表达增加，同时伴有瘦素水平降低和胰岛素敏感性增加。在怀孕期间游泳的母亲的成年后代的血清中观察到白细胞介素-6表达减少和肽PYY水平增加。我们的研究结果表明，母亲的运动是有益的，以保护后代发展肥胖，这可能是很重要的后代以及。本文的在线版本（doi：10.1186/s12986-015-0052-z）包含补充材料，可供授权用户使用。
Physical exercise induces positive alterations in gene expression involved in the metabolism of obesity. Maternal exercise provokes adaptations soon after birth in the offspring. Here, we investigated whether adult mouse offspring of swim-trained mothers is protected against the development of the deleterious effects of high fat diet (HFD). Our study comprises two parts. First, female C57BL/6 mice were divided into one sedentary and one swim-trained group (before and during pregnancy, n = 18). In the second part, adult offspring (n = 12) of trained and sedentary mothers was challenged to HFD for 16 weeks. Notably, most of the analysis was done in male offspring. Our results demonstrate that maternal exercise has several beneficial effects on the mouse offspring and protects them from the deleterious effects of HFD in the adult. Specifically, swimming during pregnancy leads to lower birth weight in offspring through 2 months of age. When subjected to HFD for 4 month in the adulthood, our study presents novel data on the male offspring’s metabolism of trained mothers. The offspring gained less weight, which was accompanied by less body fat, and they used more calories during daytime compared with offspring of sedentary mothers. Furthermore, we observed increased adiponectin expression in skeletal muscle, which was accompanied by decreased leptin levels and increased insulin sensitivity. Decreased interleukin-6 expression and increased peptide PYY levels were observed in sera of adult offspring of mothers that swam during pregnancy. Our results point to the conclusion that maternal exercise is beneficial to protect the offspring from developing obesity, which could be important for succeeding generations as well. The online version of this article (doi:10.1186/s12986-015-0052-z) contains supplementary material, which is available to authorized users.