Long-Term Risk of Sustained Hypertension in White-Coat or Masked Hypertension
Long-Term Risk of Sustained Hypertension in White-Coat or Masked Hypertension
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DOI：
10.1161/hypertensionaha.109.129882
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发表时间：
2009-08-01
期刊：
影响因子：
8.3
通讯作者：
Sega, Roberto
中科院分区：
文献类型：
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作者：
Mancia, Giuseppe;Bombelli, Michele;Sega, Roberto
白大褂（WCHT）和隐匿性高血压（MHT）是否有更大的发展为持续性高血压状态（SHT）的风险是有争议的。在动脉压监测协会研究的1412名受试者中，我们测量了办公室血压（BP）、24小时动态血压和家庭血压。WCHT诊断为办公室血压>= 140/90 mm Hg， 24小时血压平均值= 125/79 mm Hg，家庭血压>= 132/82 mm Hg。SHT诊断为办公室和24小时血压平均值或家庭血压均超过阈值，血压正常值低于阈值。10年后对受试者进行重新评估，以评估先前定义的各种情况的血压状态。第一次检查时，758例（54.1%）、225例（16.1%）、124例（8.9%）、293例（20.9%）为正常血压、WCHT、MHT和SHT。第二次检查时，血压正常者136例（18.2%）、WCHT者95例（42.6%）、MHT者56例（47.1%）发生SHT。与血压正常者相比，调整年龄和性别后，WCHT和MHT受试者发生SHT的风险明显更高(优势比分别为2.51和1.78
It is debated whether white-coat (WCHT) and masked hypertension (MHT) are at greater risk of developing a sustained hypertensive state (SHT). In 1412 subjects of the Pressioni Arteriose Monitorate e Loro Associazioni Study, we measured office blood pressure (BP), 24-hour ambulatory BP, and home BP. The condition of WCHT was identified as office BP > 140/90 mm Hg and 24-hour BP mean = 125/79 mm Hg, and home BP >= 132/82 mm Hg. SHT was identified when both office and 24-hour BP means or home BP were over threshold values and normotension was under the threshold value. Subjects were reassessed 10 years later to evaluate the BP status of the various conditions defined previously. At the first examination, 758 (54.1%), 225 (16.1%), 124 (8.9%), and 293 (20.9%) subjects were normotensive, WCHT, MHT, and SHT subjects, respectively. At the second examination, 136 normotensives (18.2%), 95 WCHT (42.6%), and 56 MHT (47.1%) subjects became SHT. As compared with normotensives, adjusting for age and sex, the risk of becoming SHT was significantly higher for WCHT and MHT subjects (odds ratio: 2.51 and 1.78, respectively; P