Interaction between job stress and the BDNF Val66Met polymorphism affects depressive symptoms in Chinese healthcare workers
Interaction between job stress and the BDNF Val66Met polymorphism affects depressive symptoms in Chinese healthcare workers
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工作压力与 BDNF Val66Met 多态性之间的相互作用影响中国医护人员的抑郁症状
DOI：
10.1016/j.jad.2018.04.089
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发表时间：
2018-08-15
影响因子：
6.6
通讯作者：
Zhang, Xiang Yang
中科院分区：
文献类型：
--
作者：
He, Shu-Chang;Wu, Shuang;Zhang, Xiang Yang
背景：长期暴露在工作压力下可导致抑郁，BDNF基因多态性可能在这一过程中起重要作用。压力x BDNFVal66Met的相互作用在抑郁症中的作用已经被广泛地利用童年压力进行了研究，但很少有研究利用成年后的慢性压力作为调节因素。本研究采用横断面设计，对北京市某综合医院243名医护人员进行问卷调查，用抑郁自评量表(SDS)评定抑郁症状，用House和Rizzo‘s工作应激量表评定工作压力，探讨慢性应激x BDNF Val66Met在中国汉族医务人员职业性抑郁中的交互作用。结果：工作压力与抑郁得分呈显著正相关(p<；0.001)。未观察到BDNFVal66Met基因对抑郁症状的显著主效应(p>；0.05)。BDNFVal66Met与工作压力对抑郁症状的交互作用有统计学意义(p<；0.05)；只有在低应激组中，Val/Val基因携带者的抑郁评分高于Met等位基因携带者，而在中、高应激组中BDNFVal66Met亚组之间的抑郁评分没有显著差异。限制：限制因素包括横断面研究设计、仅在医务人员中进行样本量较小的研究以及只分析BDNF基因的一个多态性。结论：我们的结果提示工作压力与抑郁密切相关，成年后BDNF Val66Met多态与慢性应激的交互作用可能会影响抑郁症状。
Background: Chronic exposure to job-related stress can lead to depression and BDNF polymorphism may play an important role in this process. The role of the stress x BDNF Val66Met interaction in depression has been studied widely using childhood stress, but few studies have utilized chronic stress in adulthood as a moderator. This study was to examine the chronic stress x BDNF Val66Met interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet.Methods: Using a cross-sectional design, 243 doctors and nurses were recruited from a general hospital in Beijing, and were assessed for depression with Self-rating Depression Scale (SDS), and the stress using the House and Rizzo's Work Stress Scale. The BDNF Val66Met polymorphism was genotyped.Results: There was a significant positive association between job stress and depressive scores (p < 0.001). No significant main effect of the BDNF Val66Met genotype on depressive symptoms was observed (p > 0.05). A statistically significant interaction between BDNF Val66Met and job stress on depressive symptoms was found (p < 0.05); individuals with Val/Val genotype showed a higher SDS score than Met allele carriers only in the low-stress group, without significant differences in SDS score between the BDNF Val66Met subgroups in medium-or high-stress group.Limitations: Limitations include cross-sectional study design, the small sample size only in healthcare workers and only one polymorphism in BDNF gene was analyzed.Conclusions: Our results suggest a close relationship between job-related stress and depression, and the interaction of the BDNF Val66Met polymorphism and chronic stress in adulthood may impact the depressive symptoms.