Advances in understanding the mechanisms of migraine-type photophobia.
Advances in understanding the mechanisms of migraine-type photophobia.
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DOI：
10.1097/wco.0b013e3283466c8e
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发表时间：
2011-06
影响因子：
4.8
通讯作者：
Burstein R
中科院分区：
文献类型：
--
作者：
Noseda R;Burstein R
历史上，人们对患者的畏光症进行了研究，并试图解释其机制。为了更好地理解畏光的神经基础，研究人员开发了不同的动物模型，并发表了几篇关于光加剧偏头痛机制的文章（全部在2010年）。在没有任何视觉感知的失明偏头痛患者和能够检测光线的失明偏头痛患者中进行的观察导致发现了一种新的视网膜-丘脑-皮质途径，该途径将视网膜的光信号传递到丘脑三叉神经神经元，据信在偏头痛期间对头痛强度的感知中起关键作用。光调节三叉神经血管通路的证据，以及识别光信号在介导偏头痛的伤害性通路上汇聚的途径，为光加剧偏头痛的机制提供了第一套科学数据。这些发现为偏头痛型畏光提供了神经基础。这可能导致分子靶点的鉴定和发展，以选择性地预防偏头痛期间的畏光。
Historically, photophobia was studied in patients and attempts to explain mechanisms were speculative. Efforts to understand better the neural substrate of photophobia paved way to the development of different animal models and the publication of several articles (all in 2010) on the mechanism by which light exacerbates migraine headache. Observations made in blind migraine patients devoid of any visual perception and blind migraine patients capable of detecting light have led to the discovery of a novel retino-thalamo-cortical pathway that carries photic signal from the retina to thalamic trigeminovascular neurons believed to play a critical role in the perception of headache intensity during migraine. Evidence for modulation of the trigeminovascular pathway by light and identification of the pathway through which photic signal converge on the nociceptive pathway that mediate migraine headache provide first set of scientific data on the mechanism by which light intensifies migraine headache. The findings provide a neural substrate for migraine-type photophobia. This may lead to identification and development of molecular targets for selective prevention of photophobia during migraine.