Regulation of type 1 iodothyronine deiodinase in health and disease
Regulation of type 1 iodothyronine deiodinase in health and disease
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DOI：
10.1089/thy.2005.15.835
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发表时间：
2005-08-01
期刊：
影响因子：
6.6
通讯作者：
Koenig, RJ
中科院分区：
文献类型：
--
作者：
Koenig, RJ
1型碘甲状腺原氨酸脱碘酶（D1）的主要生理功能是产生血浆中的三碘甲状腺原氨酸（T-3）。D1活性受许多因素调节，其中在人类病理生理学中最重要的可能是T-3。T-3诱导D1表达，导致甲状腺功能亢进症中常见的T-3过量。细胞因子、营养状况、性类固醇和其他因素也调节D1活性，尽管不同的器官通常表现出不同的反应。许多稳态机制可以平衡D1表达的孤立变化，如C3 H/He小鼠中基因表达的降低。两种相对常用的药物，丙基硫氧嘧啶和胺碘酮，抑制D1，这可能对循环甲状腺激素水平产生重大影响。总体而言，许多因素以复杂的方式相互作用，以建立D1水平，有助于甲状腺素（T-4）和T-3的循环浓度。
The major physiologic function of type 1 iodothyronine deiodinase (D1) is to produce triiodothyronine (T-3) for the plasma. D1 activity is regulated by numerous factors, perhaps the most important of which in human pathophysiology is T-3. T-3 induces D1 expression, contributing to the T-3 excess commonly found in hyperthyroidism. Cytokines, nutritional status, sex steroids, and other factors also regulate D1 activity, although different organs often show different responses. Numerous homeostatic mechanisms can counterbalance isolated changes in D1 expression, such as the genetically decreased expression in C3H/He mice. Two relatively commonly used drugs, propylthiouracil and amiodarone, inhibit D1, which can have substantial effects on circulating thyroid hormone levels. Overall, many factors interact in complex ways to establish D1 levels, contributing to the circulating concentrations of thyroxine (T-4) and T-3.