Duel of the fates: the role of transcriptional circuits and noise in CD4+ cells
Duel of the fates: the role of transcriptional circuits and noise in CD4+ cells
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DOI：
10.1016/j.ceb.2012.03.007
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发表时间：
2012-06-01
影响因子：
7.5
通讯作者：
Teichmann, Sarah A.
中科院分区：
文献类型：
--
作者：
Hebenstreit, Daniel;Deonarine, Andrew;Teichmann, Sarah A.
CD4+ T细胞在协调适应性免疫应答中起关键作用，并且是哺乳动物细胞分化的流行模型。虽然免疫调节似乎需要精确调整关键因子的mRNA和蛋白质表达水平，但几乎没有证据表明这是严格的情况。随机基因表达和细胞类型的可塑性与对精确度的明显需求形成鲜明对比。最近的工作提供了深入了解分子噪音的大小，以及噪音之间的关系，转录电路和表观遗传修饰在各种细胞类型。这些过程及其相互作用也将控制不同CD4+细胞类型中的基因表达模式，并决定其细胞命运。
CD4+ T cells play key roles in orchestrating adaptive immune responses, and are a popular model for mammalian cell differentiation. While immune regulation would seem to require exactly adjusted mRNA and protein expression levels of key factors, there is little evidence that this is strictly the case. Stochastic gene expression and plasticity of cell types contrast the apparent need for precision. Recent work has provided insight into the magnitude of molecular noise, as well as the relationship between noise, transcriptional circuits and epigenetic modifications in a variety of cell types. These processes and their interplay will also govern gene expression patterns in the different CD4+ cell types, and the determination of their cellular fates.