Increased long distance event-related gamma band connectivity in Alzheimer's disease
Increased long distance event-related gamma band connectivity in Alzheimer's disease
复制标题
DOI：
10.1016/j.nicl.2017.02.021
复制
发表时间：
2017-01-01
影响因子：
4.2
通讯作者：
Yener, Gorsev G.
中科院分区：
文献类型：
--
作者：
Basar, Erol;Femir, Banu;Yener, Gorsev G.
背景资料：脑振荡反应可用于非侵入性分析皮质-皮质连接，局部神经元同步，和振荡的连贯性在许多神经精神疾病，包括阿尔茨海默病（AD）。在本文中，我们研究了两个AD患者亚组（即，方法：我们研究了总共39名可能患有轻度AD的患者（根据NINCDS-ADRDA标准），这些患者被细分为未治疗（n = 21）和治疗（n = 18）（胆碱能单药治疗或与美金刚联合治疗的患者）AD组，以及21名年龄，性别和教育程度匹配的健康老年对照组。一个简单的闪光视觉范例应用于收购的感觉诱发的相干性。使用经典的视觉oddball范式引发事件相关的连贯性。在刺激后0-800 ms的持续时间内，在三个频率范围内计算长距离半球内对的感觉诱发和事件相关伽马相干性：2530 Hz，30-35 Hz和40-48 Hz。从两侧的长距离intrashempheric对额顶叶，额颞叶，额颞顶，额枕叶，中央枕叶和顶叶枕叶。结果：感觉诱发或事件相关的伽马cohesiveness显示，无论是治疗和未治疗的AD患者有显着增加的值相比，健康对照组在所有三个子γ波段。此外，治疗后的AD患者表现出显着较高的额顶叶伽玛coherency在感觉刺激和oddball范式和较低的枕顶叶coherency在oddball paradig.Conclusion：本研究表明，增加伽玛coherency是目前在AD患者的视觉感觉和认知刺激在所有的伽玛子带。因此，伽马振荡活动似乎是大脑在感觉和认知水平上的基本功能。γ相干性值的增加不是由于胆碱能治疗到任何显著程度，因为与健康对照相比，治疗和未治疗的AD患者的γ相干性值增加。使用反映大脑连接的相干值具有AD神经成像和理解与药物作用相关的大脑动力学的潜力。(C)2017作者爱思唯尔公司出版这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Background: Brain oscillatory responses can be used for non-invasive analyses of cortico-cortical connectivity, local neuronal synchronization, and coherence of oscillations in many neuropsychiatric conditions including Alzheimer's disease (AD). In the present paper, we examine sensory-evoked and event-related gamma coherences elicited by visual stimuli in three sub-gamma bands in two sub-groups of patients with AD (i.e., acetylcholinesterase-inhibitor treated and untreated) and healthy controls.Methods: We studied a total of 39 patients with probable mild AD (according to NINCDS-ADRDA criteria) who had been sub-divided into untreated (n = 21) and treated (n = 18) (patients either on cholinergic monotherapy or combined therapy with memantine) AD groups, and 21 age-, gender-, and education-matched healthy elderly controls. A simple flash visual paradigm was applied for the acquisition of sensory-evoked coherences. Event-related coherences were elicited using a classical visual oddball paradigm. Both sensory-evoked and event-related gamma coherences were calculated for long-distance intrahemispheric pairs for three frequency ranges: 2530 Hz, 30-35 Hz, and 40-48 Hz in post-stimulus 0-800 ms duration. The long-distance intrahemispheric pairs from both sides were fronto-parietal, fronto-temporal, fronto-temporoparietal, fronto-occipital, centro-occipital and parieto-occipital.Results: The sensory-evoked or event-related gamma coherences revealed that both treated and untreated AD patients had significantly increased values compared to healthy controls in all three sub-gamma bands. Moreover, the treated AD patients demonstrated significantly higher fronto-parietal gamma coherences during both sensory stimulation and oddball paradigm and lower occipito-parietal coherences during oddball paradigm in comparison to untreated AD patients.Conclusion: The present study demonstrated that an increase of gamma coherences was present in response to both visual sensory and cognitive stimulation in AD patients in all gamma sub-bands. Therefore, gamma oscillatory activity seems to be fundamental in brain functions at both the sensory and cognitive levels. The increase of gamma coherence values was not due to cholinergic treatment to any significant extent, as both treated and untreated AD patients had increased gamma coherence values compared to healthy controls. The use of coherence values reflecting brain connectivity holds potential for neuroimaging of AD and understanding brain dynamics related to the effects of medication. (C) 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).