Bioactive Self-Pumping Composite Wound Dressings with Micropore Array Modified Janus Membrane for Enhanced Diabetic Wound Healing
Bioactive Self-Pumping Composite Wound Dressings with Micropore Array Modified Janus Membrane for Enhanced Diabetic Wound Healing
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DOI：
10.1002/adfm.202005422
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发表时间：
2020-09-09
影响因子：
19
通讯作者：
Chang, Jiang
中科院分区：
文献类型：
--
作者：
Bao, Feng;Pei, Ge;Chang, Jiang
由于局部水肿引起缺血，用大量生物液治疗慢性伤口（例如糖尿病伤口）是一项重大的临床挑战。为了减轻水肿和刺激血管生成，设计了四层复合敷料，其中包括用于自泵和生物活性离子回流的微孔阵列改良Janus膜、用于高容量吸水的超吸收层和用于刺激血管生成的含有生物玻璃的生物活性层。改良的Janus膜不仅允许伤口渗出物从伤口床输送到敷料，而且还能够使含有生物活性离子的液体受控回流到伤口床以刺激血管生成。体内实验证实了复合敷料具有减轻伤口水肿、刺激血管形成、促进糖尿病伤口愈合的功能。这些结果表明，新型复合敷料是一种有前途的促进慢性伤口愈合的伤口愈合生物材料，微孔阵列Janus膜的独特特性可能会扩展其在生物医学中的应用。
Treatment of chronic wounds such as diabetic wounds with large volumes of biofluids is a significant clinical challenge due to ischemia caused by localized edema. To alleviate edema and stimulate angiogenesis, a four-layer composite dressing is designed with a micropore array modified Janus membrane for self-pumping and bioactive ion backflow, a superabsorbent layer for high capacity water absorption, and a bioactive layer containing bioglass for stimulating angiogenesis. The modified Janus membrane not only allows wound exudates transport from wound bed to the dressing, but also enables controlled backflow of bioactive ion containing fluid to the wound bed for stimulating angiogenesis. The in vivo experiment confirms the function of composite dressing in reducing wound edema, stimulating blood vessel formation and promoting diabetic wound healing. These results demonstrate that the novel composite dressing is a promising wound healing biomaterial for promoting chronic wound healing, and the unique characteristics of the micropore arrayed Janus membrane may extend its applications in biomedicine.