Commissural effects in the otolith system
Commissural effects in the otolith system
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耳石系统的连合效应
DOI：
10.1007/s002210000611
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发表时间：
2001
影响因子：
2
通讯作者：
V. J. Wilson
中科院分区：
文献类型：
--
作者：
Y. Uchino;H. Sato;M. Zakir;K. Kushiro;M. Imagawa;Y. Ogawa;S. Ono;H. Meng;X. Zhang;M. Katsuta;N. Isu;V. J. Wilson
抽象的。我们研究了是否耳石激活的第二和第三级前庭核神经元收到连合抑制从对侧的耳石斑在同一个几何平面。为此，我们进行了前庭核神经元的细胞内记录后，刺激同侧和对侧椭圆囊和囊神经。超过一半（41/72）的椭圆囊激活的前庭二级核神经元受到对侧椭圆囊神经的连合抑制。其余神经元（31/72）对侧椭圆囊神经刺激没有明显反应。约有一半（17/36）的椭圆囊激活的三级神经元也受到对侧椭圆囊神经的连合抑制。大约10%（7/67）的球囊激活的二级前庭神经元接受多突触连合抑制，而16%（11/67）接受连合易化。大多数（49/67）的囊状二级前庭神经元，几乎所有（22/23）的三级神经元，没有表现出明显的反应，刺激对侧囊状神经。目前的研究结果表明，许多椭圆囊激活前庭核神经元接受连合抑制，这可能提供了一种机制，增加前庭神经元的敏感性，以水平线性加速度和侧向倾斜的头部。囊状系统中的连合抑制不如椭圆囊系统中突出。
Abstract. We examined whether otolith-activated second- and third-order vestibular nucleus neurons received commissural inhibition from the contralateral otolithic macula oriented in the same geometric plane. For this purpose we performed intracellular recording in vestibular nucleus neurons after stimulation of the ipsi- and contralateral utricular and saccular nerves. More than half (41/72) of the utricular-activated second-order vestibular nucleus neurons received commissural inhibition from the contralateral utricular nerve. The remaining neurons (31/72) showed no visible response to contralateral utricular nerve stimulation. About half (17/36) of utricular-activated third-order neurons also received commissural inhibition from the contralateral utricular nerve. Approximately 10% (7/67) of saccular-activated second-order vestibular neurons received polysynaptic commissural inhibition, whereas 16% (11/67) received commissural facilitation. The majority (49/67) of saccular second-order vestibular neurons, and almost all (22/23) third-order neurons, showed no visible response to stimulation of the contralateral saccular nerve. The present findings suggest that many utricular-activated vestibular nucleus neurons receive commissural inhibition, which may provide a mechanism for increasing the sensitivity of vestibular neurons to horizontal linear acceleration and lateral tilt of the head. Commissural inhibition in the saccular system was less prominent than in the utricular system.