Molecular interactions of FDCs with B cells in aging.
Molecular interactions of FDCs with B cells in aging.
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DOI：
10.1016/s1044-5323(02)00059-3
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发表时间：
2002-08
影响因子：
7.8
通讯作者：
A. Szakal;Y. Aydar;P. Balogh;J. Tew
中科院分区：
文献类型：
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作者：
A. Szakal;Y. Aydar;P. Balogh;J. Tew
滤泡树突状细胞（Follicular dendritic cells, fdc）作为B细胞的辅助细胞，促进生发中心（germinal center， GC）发育。在体内，与年龄相关的缺陷在fdc的作用中得到了充分的证明。在老年小鼠中，fdc结合较少的免疫复合物（ic），产生较少的糖蛋白小体，用于B细胞的内吞作用、抗原加工和向T细胞的递呈。我们最近研究了这些缺陷是由于FDC微环境的变化还是由于FDC及其表面分子的变化。体外证据表明，通过BCR刺激B细胞和通过CD21/CD21L共同刺激B细胞的年龄相关缺陷与体内fdc捕获ic有关，这种缺陷至少在体外是可修复的。
Follicular dendritic cells (FDCs), as accessory cells to B cells, promote germinal center (GC) development. Age-related defects in the role of FDCs are well documented in vivo. In old mice, FDCs bind fewer immune complexes (ICs) and produce few iccosomes for endocytosis by B cells, antigen processing, and presentation to T cells. We recently studied whether these defects are due to changes in the FDC microenvironment or to changes in FDCs and their surface molecules. In vitro evidence suggests that age-related defects in both B cell stimulation via the BCR and co-stimulation via CD21/CD21L are related to IC-trapping by FDCs in vivo—a defect which is repairable, at least, in vitro.