Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males
Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males
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DOI：
10.1038/sj.ijo.0800483
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发表时间：
1997-09-01
影响因子：
4.9
通讯作者：
Day, INM
中科院分区：
文献类型：
--
作者：
ODell, SD;Miller, GJ;Day, INM
在1474名45-65岁的健康高加索男性中，胰岛素样生长因子II (IGF2) Apal AA纯合子的平均体重比Apal GG纯合子低4 kg (77.6 +/- 10.9 kg vs 81.6 +/- 11.5 kg， P=0.003)，杂合子（GA）中等（80.1 +/- 11.9 kg）。44例Apal AA组血清IGF-II平均浓度显著高于48例Apal GG组（683.3 +/- 146.9 ng/ml vs 614.0 +/- 124.0 ng/ml， P=0.01）。INS Pstl多态性与体重无关，与IGF2 Apal位点的连锁不平衡最小（系数0.016）。因此，与GG基因型相比，IGF2 Apal AA基因型与较低的平均体重和较高的血清IGF-II浓度相关。与AA纯合子相比，Apal GG纯合子的病理性体重指数（BMI） （bbb30 kg/m(2)）风险为1.67倍。
In 1474 healthy Caucasoid men aged 45-65 y, insulin-like growth factor II (IGF2) Apal AA homozygotes showed a mean body weight 4 kg lower than Apal GG homozygotes (77.6 +/- 10.9 kg vs 81.6 +/- 11.5 kg, P=0.003) with heterozygotes (GA) intermediate (80.1 +/- 11.9 kg). The mean serum IGF-II concentration in 44 Apal AA individuals was significantly higher than in 48 Apal GG individuals (683.3 +/- 146.9 ng/ml vs 614.0 +/- 124.0 ng/ml, P=0.01). An INS Pstl polymorphism showed no association with weight and it was also found to be in minimal linkage disequilibrium with the IGF2 Apal site (coefficient 0.016). The IGF2 Apal AA genotype is therefore associated with lower mean body weight but higher serum IGF-II concentrations than the GG genotype. Apal GG homozygotes incur a 1.67-fold risk of pathological Body Mass index (BMI) (> 30 kg/m(2)) compared with AA homozygotes.