Cardiac biopsy in Kawasaki disease
Cardiac biopsy in Kawasaki disease
复制标题
川崎病的心脏活检
DOI：
10.1007/bf02072408
复制
发表时间：
1981
影响因子：
1.5
通讯作者：
S. Onishi
中科院分区：
文献类型：
--
作者：
C. Yutani;M. Imakita;H. Ueda;J. Suzuki;T. Kamiya;S. Onishi
201例（男138例，女63例）1个月至11岁的川崎病患者接受了冠状动脉造影、超声断层扫描、心肌显像和右心室心肌活检。心外膜冠状动脉瘤26例（12.9%），多为左侧。所有病例的内皮变性和增生、水肿、瘢痕形成和纤维化（轻度至中度）均累及壁内小血管的被膜。随着时间的推移，这些变化趋于减弱。川崎病的基本病变，圆细胞心肌炎和纤维化，涉及所有的情况下，并持续存在。心肌细胞排列紊乱、异常分支、紊乱和肥大与心肌炎显著相关，但与壁外或壁内冠状动脉炎无关。由于心肌的变化，这表明，有些情况下可能终止心肌病。包括活检标本中血管和心肌变化的评分标准。
Two hundred one patients (138 boys, 63 girls), 1 month to 11 years old, with Kawasaki disease underwent coronary angiography, ultrasonic tomography, myocardial imaging, and biopsy of right ventricular myocardium. Aneurysms of epicardial coronary arteries, mostly left, occurred in 26 cases (12.9%). Degeneration and proliferation of endothelium, edema, scarring, and fibrosis, slight to moderate, involved the tunicae of intramural small vessels in all cases. These changes tended to abate with time. The basic lesion of Kawasaki disease, round-cell myocarditis and fibrosis, involved all cases and persisted. Disarrangement, abnormal branching, disarray, and hypertrophy of myocytes correlated significantly with myocarditis, but not with epimural or intramural coronary angitis. As a consequence of the myocardial changes, it is suggested that some cases may terminate as myocardiopathy. Scoring criteria for vascular and myocardial changes in biopsy specimens are included.