Elevated cancer incidence among adults with serious mental illness
Elevated cancer incidence among adults with serious mental illness
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DOI：
10.1176/appi.ps.57.7.1032
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发表时间：
2006-07-01
影响因子：
3.8
通讯作者：
Johnson, Alison T.
中科院分区：
文献类型：
--
作者：
Pandiani, John A.;Boyd, Monica M.;Johnson, Alison T.
目的：成人严重精神疾病患者的健康状况越来越受到关注。这项研究检查了佛蒙特州的数据库，以确定该人群的癌症发病率。方法：采用概率统计方法确定佛蒙特州癌症登记处和佛蒙特州精神健康治疗数据库之间的重叠。结果：患有精神疾病的成年人的癌症发病率为1.6%，是普通人群的两倍多（2.5倍）。在精神疾病患者中，50岁以下的男性风险最高（是一般人群可比组风险的6.6倍），50岁及以上的女性风险最低（是可比组风险的1.8倍）。结论：这些发现提出了关于严重精神疾病和癌症之间关系的重要问题。未来的研究应考虑生活方式因素的影响，并研究第一代和第二代抗精神病药物的潜在作用。
Objective: Research is increasingly focusing on the health status of adults with serious mental illness. This study examined databases in Vermont to determine the incidence of cancer in this population. Methods: Probabilistic statistical methods were used to determine the overlap between the Vermont Cancer Registry and Vermont mental health treatment databases. Results: The incidence of cancer for adults with mental illness was 1.6 percent, more than twice (2.5 times) that of the general population. Among persons with mental illness, elevated risk was greatest for men younger than 50 years (6.6 times the risk of a comparable group in the general population) and lowest for women aged 50 years and older (1.8 times the risk of a comparable group). Conclusions: These findings raise important questions about the relationship between serious mental illness and cancer. Future research should consider the effect of lifestyle factors, and potential effects of first- and second-generation antipsychotics should be investigated.