MRI IN TARDIVE-DYSKINESIA - SHORTENED LEFT CAUDATE-T2
MRI IN TARDIVE-DYSKINESIA - SHORTENED LEFT CAUDATE-T2
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DOI：
10.1016/0006-3223(90)90603-y
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发表时间：
1990-12-15
影响因子：
10.6
通讯作者：
OLENDORF, WH
中科院分区：
文献类型：
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作者：
BARTZOKIS, G;GARBER, HJ;OLENDORF, WH
对18例男性精神分裂症患者进行了高分辨率脑磁共振成像，其中14例累积接触抗精神病药物超过1年，4例接触时间少于3个月。 获得基底神经节的T2弛豫时间计算值。 与无迟发性运动障碍的患者（n = 5）相比，迟发性运动障碍患者（n = 9）的左尾状核T2弛豫时间显著缩短。 四名患者少于3个月的神经抑制剂暴露组表现出显着更大的变异性，他们的左尾状核T2值。 T2弛豫时间缩短可能与基底神经节中的铁水平有关，并且可能在评估迟发性运动障碍的风险中具有预测价值。
High-resolution magnetic resonance imaging of the brain was performed on 18 male schizophrenic patients, 14 with a cumulative exposure to neuroleptics of more than 1 year and 4 with less than 3 months of exposure. Calculated T2 relaxation time values were obtained for the basal ganglia. Patients with tardive dyskinesia (n = 9) had significantly shortened left caudate T2 relaxation times when compared to patients without tardive dyskinesia (n = 5). The group of four patients with fewer than 3 months' exposure to neuroleptics demonstrated a significantly greater variability of their left caudate T2 values. T2 relaxation time shortening may be related to iron levels in the basal ganglia and may be of predictive value in evaluating risk of tardive dyskinesia.