Traumatic Stress Interacts With Bipolar Disorder Genetic Risk to Increase Risk for Suicide Attempts.
Traumatic Stress Interacts With Bipolar Disorder Genetic Risk to Increase Risk for Suicide Attempts.
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创伤性压力与躁郁症遗传风险相互作用，增加自杀企图的风险。
DOI：
10.1016/j.jaac.2017.09.428
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发表时间：
2017
影响因子：
13.3
通讯作者：
中科院分区：
文献类型：
--
作者：
Wilcox,HollyC;Fullerton,JaniceM;Glowinski,AnneL;Benke,Kelly;Kamali,Masoud;Hulvershorn,LeslieA;Stapp,EmmaK;Edenberg,HowardJ;Roberts,GloriaMP;Ghaziuddin,Neera;Fisher,Carrie;Brucksch,Christine;Frankland,Andrew;Toma,Claudio;
ObjectiveBipolar disorder (BD) is one of the most heritable psychiatric conditions and is associated with high suicide risk. To explore the reasons for this link, this study examined the interaction between traumatic stress and BD polygenic risk score in relation to suicidal ideation, suicide attempt, and nonsuicidal self-injury (NSSI) in adolescent and young adult offspring and relatives of persons with BD (BD-relatives) compared with adolescent and young adult offspring of individuals without psychiatric disorders (controls).MethodData were collected from 4 sites in the United States and 1 site in Australia from 2006 through 2012. Generalized estimating equation models were used to compare rates of ideation, attempts, and NSSI between BD-relatives (n = 307) and controls (n = 166) and to determine the contribution of demographic factors, traumatic stress exposure, lifetime mood or substance (alcohol/drug) use disorders, and BD polygenic risk score.ResultsAfter adjusting for demographic characteristics and mood and substance use disorders, BD-relatives were at increased risk for suicidal ideation and attempts but not for NSSI. Independent of BD-relative versus control status, demographic factors, or mood and substance use disorders, exposure to trauma within the past year (including bullying, sexual abuse, and domestic violence) was associated with suicide attempts (p= .014), and BD polygenic risk score was marginally associated with attempts (p= .061). Importantly, the interaction between BD polygenic risk score and traumatic event exposures was significantly associated with attempts, independent of demographics, relative versus control status, and mood and substance use disorders (p= .041).ConclusionBD-relatives are at increased risk for suicide attempts and ideation, especially if they are exposed to trauma and have evidence of increased genetic vulnerability.
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自杀行为的全基因组关联研究：综述
影响因子：
5.6
作者：
M. Sokolowski;J. Wasserman;D. Wasserman
通讯作者：
D. Wasserman
影响因子：
--
作者：
Nurnberger JI Jr;McInnis M;Reich W;Kastelic E;Wilcox HC;Glowinski A;Mitchell P;Fisher C;Erpe M;Gershon ES;Berrettini W;Laite G;Schweitzer R;Rhoadarmer K;Coleman VV;Cai X;Azzouz F;Liu H;Kamali M;Brucksch C;Monahan PO
通讯作者：
Monahan PO
影响因子：
10.6
作者：
Fullerton, Janice M.;Donald, Jennifer A.;Schofield, Peter R.
通讯作者：
Schofield, Peter R.
影响因子：
6.6
作者：
Brown, GR;McBride, L;Williford, WO
通讯作者：
Williford, WO
影响因子：
11
作者：
Sokolowski, M.;Wasserman, J.;Wasserman, D.
通讯作者：
Wasserman, D.