Simulation of massive periretinal proliferation by autotransplantation of retinal pigment epithelial cells in rabbits.
Simulation of massive periretinal proliferation by autotransplantation of retinal pigment epithelial cells in rabbits.
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DOI：
10.1016/0002-9394(81)90352-4
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发表时间：
1981
影响因子：
4.2
通讯作者：
N. Radtke;Yasuo Tano;David B. Chandler;R. Machemer
中科院分区：
文献类型：
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作者：
N. Radtke;Yasuo Tano;David B. Chandler;R. Machemer
我们比较了新鲜收获的和组织培养的(250,000)视网膜色素上皮细胞自体移植到兔玻璃体内所产生的损害的临床模式、组织学表现和电子显微镜表现。收获的细胞和培养的细胞都形成了玻璃体内的线条、牵引分离和视网膜皱褶，类似于人类视网膜周围大规模增殖的最显著特征。这两种类型的视网膜色素上皮细胞产生的线束含有类似肌成纤维细胞的细胞，这可能解释了线束的收缩能力。临床、组织学和电子显微镜观察与注射组织培养皮肤成纤维细胞的眼睛相似。
We compared the clinical pattern, the histologic findings, and the electron microscopic appearance of lesions produced by the autotransplantation into rabbit vitreous of freshly harvested and tissue-cultured (250,000) retinal pigment epithelial cells. Both harvested and cultured cells formed intravitreal strands, traction detachments, and retinal puckers, resembling the most prominent features of massive periretinal proliferation in humans. Strands produced by both types of retinal pigment epithelial cells contained cells resembling myofibroblasts which may explain the contractability of the strand. The clinical, histologic, and electron microscopic observations were similar to those found in eyes injected with tissue-cultured skin fibroblasts.