Dynamics of gene regulatory networks with cell division cycle.
Dynamics of gene regulatory networks with cell division cycle.
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DOI：
10.1103/physreve.70.011909
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发表时间：
2004-07
期刊：
影响因子：
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通讯作者：
Luonan Chen;Ruiqi Wang;Tetsuya J. Kobayashi;K. Aihara
中科院分区：
文献类型：
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作者：
Luonan Chen;Ruiqi Wang;Tetsuya J. Kobayashi;K. Aihara
本文重点研究了基因调控网络的非线性动力学建模和分析，考虑了细胞分裂周期的DNA复制过程，特别是开关和振荡器的合成网络。我们推导出两种模型，分别对应于真核细胞和原核细胞。一个生物学上合理的三基因模型（乳糖，tetR，和cI）和阻遏开关和振荡器的例子来说明我们的理论结果。我们表明，细胞周期可能发挥重要作用，由于基因调控网络的非线性动力学，虽然基因表达通常是由转录因子严格控制的基因调控。
This paper focuses on modeling and analyzing the nonlinear dynamics of gene regulatory networks with the consideration of a cell division cycle with duplication process of DNA, in particular for switches and oscillators of synthetic networks. We derive two models that may correspond to the eukaryotic and prokaryotic cells, respectively. A biologically plausible three-gene model ( lac, tetR, and cI ) and a repressilator as switch and oscillator examples are used to illustrate our theoretical results. We show that the cell cycle may play a significant role in gene regulation due to the nonlinear dynamics of a gene regulatory network although gene expressions are usually tightly controlled by transcriptional factors.