Facile synthesis of chiral [2,3]-fused hydrobenzofuran via asymmetric Cu(i)-catalyzed dearomative 1,3-dipolar cycloaddition
Facile synthesis of chiral [2,3]-fused hydrobenzofuran via asymmetric Cu(i)-catalyzed dearomative 1,3-dipolar cycloaddition
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通过不对称 Cu(i) 催化脱芳香 1,3-偶极环加成轻松合成手性 [2,3]-稠合氢苯并呋喃
DOI：
10.1039/c8cc09226e
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发表时间：
2019-01-14
影响因子：
4.9
通讯作者：
Guo, Hai-Ming
中科院分区：
文献类型：
--
作者：
Liang, Lei;Niu, Hong-Ying;Guo, Hai-Ming
Intermolecular asymmetric dearomative 1,3-dipolar cycloaddition of 2-nitrobenzofurans with azomethine ylides was enabled by using a chiral Cu(i)/(S,S-p)-Pr-i-Phosferrox catalyst. As a result, a series of highly stereoselective chiral [2,3]-fused hydrobenzofurans possessing four contiguous stereogenic centers were obtained with good to high yields, diastereoselectivities and enantioselectivities. The reaction has broad substrate scope tolerating various functional groups.
