A systematic nomenclature for mammalian tropomyosin isoforms.
A systematic nomenclature for mammalian tropomyosin isoforms.
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DOI：
10.1007/s10974-014-9389-6
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发表时间：
2015-04
影响因子：
2.7
通讯作者：
Gunning PW
中科院分区：
文献类型：
--
作者：
Geeves MA;Hitchcock-DeGregori SE;Gunning PW
原肌球蛋白是动物和真菌中普遍存在的蛋白质，与肌动蛋白细胞骨架相关，参与稳定肌动蛋白丝并调节肌动蛋白丝与其他肌动蛋白结合蛋白的相互作用。该蛋白质以其在调节肌肉收缩中肌动蛋白和肌球蛋白之间的相互作用中的作用而闻名，但近年来，它作为细胞骨架的组织和动力学的主要参与者的作用已得到越来越多的认识。在哺乳动物中，Tpm 由四个不同的基因表达，每个基因的交替剪接可产生总共多达 40 种不同的 mRNA 变体，其中大多数以蛋白质形式表达。随着这些不同亚型的作用开始被破译，我们期待原肌球蛋白研究的复兴。然而，我们相信这种复兴受到原肌球蛋白亚型命名系统的混乱的限制。这导致即使是经验丰富的工作人员也很难协调在不同实验室和不同时间完成的工作。我们在此提出基于当前最佳实践的原肌球蛋白的系统命名法。我们建议采用这些名称，并在此处包含对蛋白质序列的备用名称和登录号表的交叉引用。国家生物技术信息中心 (NCBI) 网站已修改，包含人类、小鼠和大鼠基因的命名法。
Tropomyosin, a ubiquitous protein in animals and fungi, is associated with the actin cytoskeleton and is involved with stabilising actin filaments and regulating the interaction of the filament with other actin binding proteins. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction but in recent years its role as a major player in the organisation and dynamics of the cytoskeleton has been increasingly recognised. In mammals Tpm is expressed from four distinct genes and alternate splicing of each gene can produce a total of up to 40 different mRNA variants most of which are expressed as proteins. We are expecting a renaissance in the study of tropomyosins as the roles of these different isoforms are beginning to be deciphered. However, it is our belief that such a renaissance is being limited by confusion over the naming systems for the tropomyosin isoforms. These result in even experienced workers struggling to reconcile work done in different laboratories and at different times. We propose here a systematic nomenclature for tropomyosin based on the best current practice. We recommend the adoption of these names and a cross-reference to the table of alternate names and accession numbers for protein sequences is included here. The National Center for Biotechnology Information (NCBI) website has been amended to include the nomenclature for the human, mouse and rat genes.