Atypical hemispheric language dominance in left temporal lobe epilepsy as a result of the reorganization of language functions
Atypical hemispheric language dominance in left temporal lobe epilepsy as a result of the reorganization of language functions
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DOI：
10.1016/s1525-5050(03)00119-7
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发表时间：
2003-08-01
影响因子：
2.6
通讯作者：
Rektor, I
中科院分区：
文献类型：
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作者：
Brázdil, M;Zákopcan, J;Rektor, I
通过颈动脉内短效巴比妥类注射（Wada 测试）确定的半球语言优势，对 44 名患有医学上难治性左颞叶癫痫 (n = 26) 或右撇子 (n = 18) 颞叶癫痫 (TLE) 的右利手患者进行了回顾性评估。在所有接受调查的患者中，13.6% 的患者表现出非典型半球语言优势（右侧或双侧）。左侧 TLE 中观察到完全左半球优势的偏离率 (23.1%) 明显高于右侧 TLE (0%)。癫痫发作时的患者年龄被证明是影响左侧颞叶癫痫非典型言语发展的关键变量。具有非典型语言表征的左侧 TLE 患者癫痫发作时的平均患者年龄为 5.61 岁，而具有左半球语言优势的患者则为 13.13 岁。我们的结果有力地支持了从左颞叶结构传播的癫痫样活动对早期脑损伤患者语言功能重组的影响。 (C) 2003 年爱思唯尔科学（美国）。版权所有。
Hemispheric language dominance, as determined by intracarotid short-acting barbiturate injections (Wada testing), was retrospectively evaluated in 44 right-handed patients with medically intractable left (n = 26) or right (n = 18) temporal lobe epilepsy (TLE). Atypical hemispheric language dominance (right or bilateral) was revealed in 13.6% of all patients investigated. A significantly higher rate of deviance from complete left hemisphere dominance was observed in left TLE (23.1%) than in right TLE (0%). Patient age at the time of seizure onset was proven a critical variable affecting atypical speech development in left TLE. The mean patient age at the time of seizure onset in left TLE patients with atypical language representation was 5.61 years, but was 13.13 years in patients with left hemisphere language dominance. Our results strongly support the influential impact of epileptiform activity spreading from the left temporal lobe structures on the reorganization of language functions in patients with early brain injury. (C) 2003 Elsevier Science (USA). All rights reserved.