Pyrazolofluostatins A-C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160
Pyrazolofluostatins A-C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160
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吡唑氟他汀 A-C，来自南海衍生小单孢菌 SCSIO N160 的吡唑稠合苯并[a]芴
DOI：
10.1021/acs.orglett.6b03745
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发表时间：
2017-02-03
期刊：
影响因子：
5.2
通讯作者：
Zhang, Changsheng
中科院分区：
文献类型：
--
作者：
Zhang, Wenjun;Yang, Chunfang;Zhang, Changsheng
吡唑氟他汀 A-C (1-3) 是三种具有前所未有的碳骨架的新型苯并[a]-芴，从南海衍生的小单孢菌 SCSIO N160 中获得。通过广泛的光谱分析阐明了它们的结构。吡唑氟他汀 A (1) 的结构通过 X 射线晶体学分析得到证实。值得注意的是，1-3具有苯并[cd]茚并[2,1-f]吲唑骨架和吡唑稠合的6/5/6/6/5五环系统。吡唑氟他汀 A (I) 显示出中等的抗氧化活性 (EC50 48.6 muM)。
Pyrazolofluostatins A-C (1-3), three new benzo[a]-fluorenes with an unprecedented carbon skeleton, were obtained from the South China Sea-derived Micromonospora rosaria SCSIO N160. Their structures were elucidated by extensive spectroscopic analyses. The structure of pyrazolofluostatin A (1) was confirmed by X-ray crystallographic analysis. Notably, 1-3 possessed a benzo[cd]indeno[2,1-f]indazol skeleton with a pyrazole-fused 6/5/6/6/5 pentacydic ring system. Pyrazolofluostatin A (I) showed moderate antioxidation activity (EC50 48.6 mu M).