Methylated constituents of heterogeneous nuclear RNA: Presence in blocked 5′ terminal structures
Methylated constituents of heterogeneous nuclear RNA: Presence in blocked 5′ terminal structures
复制标题
异质核 RNA 的甲基化成分：5 末端结构中的存在被阻断
DOI：
10.1016/0092-8674(75)90068-9
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发表时间：
1975
期刊：
影响因子：
64.5
通讯作者：
Fritz M. Rottman
中科院分区：
文献类型：
--
作者：
R. P. Perry;D. Kelley;K. Friderici;Fritz M. Rottman
A substantlal portion of the hnRNA of mouse L cells contains internal residues of Nb-methyl adenyiate and blocked 5’terminal sequences which are apparently of the type m7G5’ppps’ YmpZp..., in which 7-methyl guanosine is joined by a V-5’pyrophosphate linkage to a 2’-0-methyiated residue, Ym. These sequences are indistinguishable from those comprising one of the two classes of blocked 5’sequences found in mRNA, and are quite distinct from those comprising the other class. The remarkable similarity in 5’terminal methyiated sequences of hnRNA and a major fraction of mRNA appears to extend even to the relative occurrence of each of the four 2’-0-methylated species in position Ym.
