Deterioration of naming nouns versus verbs in primary progressive aphasia
Deterioration of naming nouns versus verbs in primary progressive aphasia
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DOI：
10.1002/ana.10812
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发表时间：
2004-02-01
影响因子：
11.2
通讯作者：
Ken, L
中科院分区：
文献类型：
--
作者：
Hillis, AE;Oh, S;Ken, L
在局灶性脑损伤或退行性疾病中，命名名词与动词的不成比例损伤以及相反的模式已有报道，这表明名词和动词的加工可能依赖于不同的大脑区域。然而，目前还不清楚是口语词汇的形式还是名词和动词的意义(或两者都有)依赖于不同的神经区域。我们测试了非流利性原发性进行性失语症(非流利性PPA；n=15)、流利性原发性进行性失语(流利性PPA，n=7)和肌萎缩侧索硬化症伴额颞叶痴呆(ALS-FTD；n=6)患者的名词和动词的口头和书面命名，这些名称和动词的难度匹配。不流利的PPA和ALS-FTD患者，无论是单独还是作为小组，在动词命名上的损害显著高于名词命名，在口头命名上的损害显著高于书面命名。流利的PPA患者在词类和情态方面都表现出相反的模式，名词命名比动词命名明显受损，书面命名明显比口头命名受损。结果表明，大脑的不同区域对于接触口头和书面形式的动词和名词是必不可少的，这些神经区域在不同形式的PPA中可能受到不同程度的损害。
Disproportionate impairment of naming nouns versus verbs and the opposite pattern have been reported in cases of focal brain damage or degenerative disease, indicating that processing of nouns and verbs may rely on different brain regions. However, it has not been clear whether it is the spoken word forms or the meanings (or both) of nouns and verbs that depend on separate neural regions. We tested oral and written naming of nouns and verbs, matched in difficulty, in patients with nonfluent primary progressive aphasia (nonfluent PPA; n=15), fluent primary progressive aphasia (fluent PPA, n=7), and amyotrophic lateral sclerosis with frontotemporal dementia (ALS-FTD; n=6). Patients with nonfluent PPA and ALS-FTD, both individually and as groups, were significantly more impaired on verb naming than on noun naming and significantly more impaired on oral naming than written naming. Patients with fluent PPA showed the opposite pattern for both word class and modality, significantly more impaired naming of nouns versus verbs and significantly more impaired written versus oral naming. Results indicate that separate regions of the brain are essential for access to oral and written word forms of verbs and nouns, and that these neural regions can be differentially damaged in separate forms of PPA.