Neuropathologic differences by race from the National Alzheimer's Coordinating Center.
Neuropathologic differences by race from the National Alzheimer's Coordinating Center.
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DOI：
10.1016/j.jalz.2016.03.004
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Dickson DW
中科院分区：
文献类型：
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作者：
Graff-Radford NR;Besser LM;Crook JE;Kukull WA;Dickson DW
与白人相比，非裔美国人（AA）有更高的痴呆患病率，不同的遗传标记和更高的血管危险因素。然而，病理基础是未知的。我们使用的神经病理学和临床数据110 AA和2500高加索人谁是痴呆死亡前。比较各组的人口统计学、认知、载脂蛋白E（ApoE）基因型、合并症以及临床和神经病理学特征。AA和高加索人在人口统计学、死亡前末次访视时的认知、ApoE基因型、高血压、主要临床诊断和AD、脑血管疾病（CVD）和其他神经病理学（如路易体病（LBD））方面存在差异。与白人相比，AA患者中AD、LBD和CVD病理更常见，TDP和FTLD-tau较不常见。ApoE占AD神经病理学差异的大部分。如果重复，观察到的种族之间的潜在神经病理学差异将对公共卫生政策以及临床试验的招募和解释非常重要。
Compared to Caucasians, African Americans (AA) have higher dementia prevalence, different genetic markers and higher vascular risk factors. However, pathological underpinnings are unknown. We used neuropathological and clinical data on 110 AA and 2500 Caucasians who were demented before death. The groups were compared regarding demographics, cognition, apolipoprotein E (ApoE) genotype, comorbidities, and clinical and neuropathological characteristics. AA and Caucasians differed in their demographics, cognition at the last visit before death, ApoE genotype, presence of hypertension, primary clinical diagnoses, and AD, cerebrovascular disease (CVD), and other neuropathologies such as Lewy body disease (LBD). AD, LBD and CVD pathology were more common and TDP and FTLD-tau less common in AA than in Caucasians. ApoE accounted for most of the AD neuropathological differences. If replicated, the observed differences in underlying neuropathology by race will be important for public health policy, and recruitment for and interpreting of clinical trials.