The roles and therapeutic potentials of Ephs and ephrins in lung cancer
The roles and therapeutic potentials of Ephs and ephrins in lung cancer
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Ephs 和 ephrins 在肺癌中的作用和治疗潜力。
DOI：
10.1016/j.yexcr.2012.08.005
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发表时间：
2013-01-15
影响因子：
3.7
通讯作者：
Xie, Dong
中科院分区：
文献类型：
--
作者：
Li, Jing-Jing;Xie, Dong
Eph受体及其膜结合的肝配蛋白配体密切参与正常胚胎发生过程中的胚胎模式化、神经元靶向和血管发育。近年来，越来越多的研究表明它们参与了各种癌症的发展。在这篇综述中，我们集中在他们参与肺癌。在此背景下，我们总结了他们的异常表达，他们的促癌或抑癌作用以及相关机制，和他们的潜在的药物靶点在肺癌。(c)2012 Elsevier Inc. All rights reserved.
Eph receptors and their membrane-bound ephrin ligands are intimately involved in embryonic patterning, neuronal targeting, and vascular development during normal embryogenesis. In recent years, a growing number of studies revealed their participation in the development of various cancers. In this review, we concentrate on their involvement in lung cancer. In this context, we summarize their aberrant expressions, their pro- or anti-oncogenic effects as well as related mechanisms, and their potential as drug targets in lung cancer. (c) 2012 Elsevier Inc. All rights reserved.