Absence of spectrally specific lateral inputs to midget ganglion cells in primate retina
Absence of spectrally specific lateral inputs to midget ganglion cells in primate retina
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DOI：
10.1038/381613a0
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发表时间：
1996-06-13
期刊：
影响因子：
64.8
通讯作者：
Sterling, P
中科院分区：
文献类型：
--
作者：
Calkins, DJ;Sterling, P
视觉信息通过视网膜神经节细胞传递到大脑。侏儒神经节细胞通过将来自感受野“中心”的兴奋与来自感受野“周围”的侧抑制相加来提供精细空间视觉（1，2），所述感受野“中心”接收来自中央视网膜中的单个视锥的输入，所述感受野“周围”接收来自许多周围视锥的输入。侏儒神经节细胞也被认为提供颜色对立视觉（1-6），因为中心兴奋来自一种光谱类型的视锥，而周围抑制来自另一种类型的视锥细胞（4，6）。两种主要的视锥细胞类型，即对中（M）波长敏感的视锥细胞和对长（L）波长敏感的视锥细胞，在灵长类动物的中央视网膜中数量相等且随机分布（7-9），因此光谱均匀的周围环境要求介导横向相互作用的细胞（水平或无长突细胞）仅从一种视锥细胞类型接收选择性输入。水平细胞不能做到这一点，因为它们不加区别地接受来自M和L视锥细胞的输入（10-12）。在这里，我们报告说，无长突细胞连接到侏儒神经节细胞同样是不分青红皂白的，光谱特异性的抑制布线的情况下提出了怀疑侏儒神经节细胞参与色觉，并建议，颜色的一致性，而不是由不同类型的神经节细胞传达。
VISUAL information is conveyed to the brain by retinal ganglion cells. Midget ganglion cells serve fine spatial vision(1,2) by summing excitation from a receptive field 'centre', receiving input from a single cone in the central retina, with lateral inhibition from a receptive field 'surround', receiving input from many surrounding cones, Midget ganglion cells are also thought to serve colour opponent vision(1-6) because the centre excitation is from a cone of one spectral type, while the surround inhibition is from cones of the other type(4,6). The two major cone types, middle(M)- and long(L)wavelength sensitive, are equally numerous and randomly distributed in the primate central retina(7-9), so a spectrally homogeneous surround requires that the cells mediating lateral interactions (horizontal or amacrine cells) receive selective input from only one cone type. Horizontal cells cannot do this because they receive input indiscriminately from M and L cones(10-12). Here we report that the amacrine cells connected to midget ganglion cells are similarly indiscriminate, The absence of spectral specificity in the inhibitory wiring raises doubt about the involvement of midget ganglion cells in colour vision and suggests that colour opponency may instead be conveyed by a different type of ganglion cell.