Sphingosine 1-phosphate signalling
Sphingosine 1-phosphate signalling
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DOI：
10.1242/dev.094805
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发表时间：
2014-01-01
期刊：
影响因子：
4.6
通讯作者：
Hla, Timothy
中科院分区：
文献类型：
--
作者：
Mendelson, Karen;Evans, Todd;Hla, Timothy
1-磷酸鞘氨醇(S1P)是鞘磷脂代谢形成的一种脂质介质。在脊椎动物中，S1P通过G蛋白偶联的S1P受体分泌到细胞外环境和信号中，调节细胞与细胞和细胞与基质的黏附，从而影响细胞的迁移、分化和存活。S1P受体的表达和定位是动态调节的，控制着血管的发育、血管的稳定性和免疫细胞的运输。此外，胚胎发生中的关键事件，如血管发生、心脏发生、肢体发育和神经发生，都受到S1P信号的调控。在这里，以及附带的海报中，我们提供了S1P信号在发育和疾病中的概述。
Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival. The expression and localization of S1P receptors is dynamically regulated and controls vascular development, vessel stability and immune cell trafficking. In addition, crucial events during embryogenesis, such as angiogenesis, cardiogenesis, limb development and neurogenesis, are regulated by S1P signalling. Here, and in the accompanying poster, we provide an overview of S1P signalling in development and in disease.