Rectified cross-axis adaptation of the vestibulo-ocular reflex in rhesus monkey.
Rectified cross-axis adaptation of the vestibulo-ocular reflex in rhesus monkey.
复制标题
恒河猴前庭眼反射的校正横轴适应。
DOI：
10.1111/j.1749-6632.2002.tb02877.x
复制
发表时间：
2002
影响因子：
5.2
通讯作者：
Zee,DS
中科院分区：
文献类型：
--
作者：
Walker,MF;Zee,DS
In order to maintain perfect gaze stability, the vestibulo-ocular reflex (VOR) must be appropriately calibrated in three dimensions. Prior experiments have shown that not only the gain but also the direction of the VOR can be adaptively modified. Directional (cross-axis) VOR plasticity is dependent upon integrity of the vestibulo-cerebellum. 1 The usual paradigm for cross-axis adaptation pairs a sinusoidal head rotation about one axis (eg, yaw) with an orthogonally moving visual stimulus (eg, vertical) that has the same frequency and phase. After prolonged exposure to this stimulus, the response to yaw-axis rotation alone includes a vertical component. This process was modeled by Robinson using a 3× 3 brainstem matrix to map inputs from semicircular canal pairs to pairs of eye muscles. 2 In patients with cerebellar disease, we have observed a pattern of cross-coupling in which there is an inappropriate upward eye velocity during yaw-axis rotation in either direction. 3 This differs from the typical cross-axis adaptation experiment, in which the vertical component changes direction with the horizontal component. For example, when the head moves to the right, the stimulus moves up, and when the head moves to the left, the stimulus moves down. We asked whether the normal VOR could be trained to produce the response pattern seen in patients. In three rhesus monkeys, we used the magnetic field search coil technique to record responses to yaw-axis rotation before, during, and after adaptation. Animals were rotated (0.5 Hz, 30–62 degrees/sec peak velocity) about the yaw axis for 35–120 minutes. During rotation, they viewed (and followed) a random dot optokinetic stimulus (also 0.5 Hz) that was in phase with the chair, except that it moved upward during each half-cycle of rotation. We term this “rectified cross-axis adaptation” because the velocity profile of the visual stimulus is a rectified sine. Before and after this adaptation, the response to yaw axis rotation was recorded, both in the dark and with viewing of a space-fixed center target (to maintain orbital position). Analysis was performed on the latter data because visual fixation did not suppress the effect of adaptation.
对从行为动物收集的尖峰序列数据进行计算机分析的定量方法
影响因子：
2.9
作者：
J. Macpherson;J. Aldridge
通讯作者：
J. Aldridge
影响因子：
1.7
作者：
R. Blake;R. Overton
通讯作者：
R. Overton
双眼竞争：中枢或外周选择过程？
DOI：
--
发表时间：
1978
期刊：
影响因子：
--
作者：
P. Walker
通讯作者：
P. Walker