Product identification and safety evaluation of aflatoxin B1 decontaminated by electrolyzed oxidizing water.
Product identification and safety evaluation of aflatoxin B1 decontaminated by electrolyzed oxidizing water.
复制标题
DOI：
10.1021/jf303478y
复制
发表时间：
2012-09
影响因子：
6.1
通讯作者：
Ke Xiong;Hai Liu;L. Li
中科院分区：
文献类型：
--
作者：
Ke Xiong;Hai Liu;L. Li
In this study with aflatoxin-contaminated peanuts, the effectiveness of electrolyzed oxidizing water (EOW) in the decontamination of aflatoxin B(1) was investigated. The aflatoxin B(1) content was markedly reduced upon treatment with EOW, particularly with neutral electrolyzed oxidizing water (NEW). The conversion product of EOW treatment was isolated and identified as 8-chloro-9-hydroxy aflatoxin B(1) (compound 1), which is an amphiphilic molecule, in contrast to fat-soluble aflatoxin B(1). A mutagenic response study revealed that the number of revertants per plate after treatment of bacterial strains TA-97, TA-98, TA-100, and TA-102 with NEW was within the standard value range. The HepG2 cell viability assay yielded an IC(50) value of compound 1 approximately 150 mM. This study indicates that EOW had the ability to decontaminate aflatoxin B(1), and the conversion product, compound 1, did not exhibit mutagenic activity or cytotoxic effects.
