Reproducibility of LVEF, LV volumes, and LV mass between Rubidium-82 PET/CT scans in young healthy volunteers using two commercially available software packages
Reproducibility of LVEF, LV volumes, and LV mass between Rubidium-82 PET/CT scans in young healthy volunteers using two commercially available software packages
复制标题
DOI：
10.1007/s12350-019-01698-9
复制
发表时间：
2020-08-01
影响因子：
2.4
通讯作者：
Hasbak, Philip
中科院分区：
文献类型：
--
作者：
Byrne, Christina;Kjaer, Andreas;Hasbak, Philip
背景心电图门控铷-82正电子发射断层扫描/计算机断层扫描（Rb-82-PET/CT）可获得总体功能参数。然而，这些数据的重现性未得到澄清。我们的目的是研究左心室射血分数（LVEF），收缩末期容积（ESV），舒张末期容积（EDV）和左心室（LV）质量之间的两次扫描和两个商业软件包之间的再现性。方法和结果40名健康年轻志愿者接受了两次（82）Rb-PET/CT静息和腺苷负荷扫描，获得了整体功能参数。采用双4DM（4DM）和定量门控SPECT（QGS）进行分析。平均（+/- SD）年龄为24 ± 4岁，50%为男性。在扫描之间发现所有参数的高再现性，这对于两个软件包都是如此。4型糖尿病患者静息时LVEF：平均差异（95% CI）-1.1（-3.0至0.8），P= 0.25，一致性限度：-12.8至10.6。软件包之间的所有功能参数均存在显着差异（P< .0001）。结论（82）Rb-PET/CT测量LVEF、ESV、EDV及左室质量具有较高的重复性。然而，当比较两个软件包时，参数测量之间的一致性较差。因此，整体功能参数测量是可靠的，但在研究中和比较绝对值时应使用相同的软件包。
Background Global functional parameters are available from electrocardiographic gated Rubidium-82 positron emission tomography/computed tomography (Rb-82-PET/CT). However, the reproducibility of these data is not clarified. We aimed to investigate reproducibility of left ventricular ejection fraction (LVEF), endsystolic volume (ESV), enddiastolic volume (EDV), and left ventricular (LV) mass between two scans and between two commercially available software packages. Methods and Results Forty healthy young volunteers underwent two(82)Rb-PET/CT rest and adenosine stress scans obtaining global functional parameters. Corridor4DM (4DM) and Quantitative Gated SPECT (QGS) were used for analyses. Mean (+/- SD) age was 24 +/- 4 years and 50% were men. High reproducibility of all parameters was found between scans and this was true for both software packages. LVEF at rest with 4DM: mean difference (95% CI) - 1.1 (- 3.0 to 0.8),P= .25, limits of agreement: - 12.8 to 10.6. Significant differences were found between software packages on all functional parameters (P< .0001). Conclusion High reproducibility was found between scans when measuring LVEF, ESV, EDV, and LV mass from(82)Rb-PET/CT. However, concordance between parameter measures was poor when comparing the two software packages. Thus, global functional parameter measures are reliable, but the same software package should be used within a study and when comparing absolute values.