Non-coding functions of alternative pre-mRNA splicing in development.
Non-coding functions of alternative pre-mRNA splicing in development.
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DOI：
10.1016/j.semcdb.2015.10.018
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发表时间：
2015-12
影响因子：
7.3
通讯作者：
Makeyev EV
中科院分区：
文献类型：
--
作者：
Mockenhaupt S;Makeyev EV
高等真核生物中的大多数信使RNA前体（pre-mRNAs）经历选择性剪接以产生一种以上的成熟产物。通过靶向开放阅读框区域，该过程增加了蛋白质同种型的多样性，超过了基因组的标称编码能力。然而，选择性剪接也经常控制细胞和生物体基因表达程序的输出水平和时空特征。在这里，我们讨论了这些非编码功能的选择性剪接有助于通过mRNA的稳定性，翻译效率和细胞定位的调节发展。
A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo alternative splicing to generate more than one mature product. By targeting the open reading frame region this process increases diversity of protein isoforms beyond the nominal coding capacity of the genome. However, alternative splicing also frequently controls output levels and spatiotemporal features of cellular and organismal gene expression programs. Here we discuss how these non-coding functions of alternative splicing contribute to development through regulation of mRNA stability, translational efficiency and cellular localization.