Iridium-192 brachytherapy in combination with interstitial microwave-induced hyperthermia for malignant glioma.
Iridium-192 brachytherapy in combination with interstitial microwave-induced hyperthermia for malignant glioma.
复制标题
铱 192 近距离放射治疗联合间质微波诱导热疗治疗恶性胶质瘤。
DOI：
10.1159/000100728
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Douple,EB
中科院分区：
文献类型：
--
作者：
Roberts,DW;Strohbehn,JW;Coughlin,CT;Ryan,TP;Lyons,BE;Douple,EB
一项评估热疗联合l92ir近距离放射治疗（60 Gy）治疗恶性胶质瘤的可行性和安全性的I期临床试验目前包括14名患者。采用立体定向植入后置导管和微波（915或2450 MHz）天线阵列诱导热疗（42-43°C肿瘤边缘60分钟）。沿着每根导管记录的测温证实了该技术加热此类体积的一般能力，但记录了热非均质性。既往神经功能缺损的短暂或永久性恶化在7例患者中最为常见。
A phase I clinical trial assessing the feasibility and safety of hyperthermia in combination withl92Ir brachytherapy (60 Gy) for the treatment of malignant glioma now includes 14 patients. Hyperthermia (42–43 °C at tumor margin for 60 min) has been induced using stereotactically implanted afterloading catheters and a microwave (915 or 2,450 MHz) antenna array. Thermometry recorded along each catheter confirms the general ability of the technique to heat such volumes, but thermal heterogeneities are documented. Transient or permanent worsening of previous neurologic deficit, seen in 7 patients, has been the most common morbidity.