Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997
Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997
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DOI：
10.1086/338820
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发表时间：
2002-05-01
影响因子：
11.8
通讯作者：
Chan, PKS
中科院分区：
文献类型：
--
作者：
Chan, PKS
人类感染甲型禽流感（H5N1）病毒的第一次爆发是在1997年香港。18人被确认感染，其中6人死亡。人类直接从鸡身上获得感染，没有中间宿主的参与。当局于一九九七年十二月底在全港屠宰超过一百五十万只鸡，遏止禽流感爆发。H5 N1感染的临床范围包括无症状感染、致命性肺炎和多器官衰竭。反应性噬血细胞综合征是最具特征性的病理学发现，可能导致严重感染患者中观察到的淋巴细胞减少症、肝功能障碍和凝血功能异常。应用逆转录聚合酶链反应和单克隆抗体免疫荧光技术进行快速诊断，在暴发疫情的管理中具有重要的临床价值。香港爆发H5N1禽流感的经验，突显持续监察人类及其他动物流感病毒株的重要性。
The first outbreak of avian influenza A(H5N1) virus in humans occurred in Hong Kong in 1997. Infection was confirmed in 18 individuals, 6 of whom died. Infections were acquired by humans directly from chickens, without the involvement of an intermediate host. The outbreak was halted by a territory-wide slaughter of more than 1.5 million chickens at the end of December 1997. The clinical spectrum of H5N1 infection ranges from asymptomatic infection to fatal pneumonitis and multiple organ failure. Reactive hemophagocytic syndrome was the most characteristic pathologic finding and might have contributed to the lymphopenia, liver dysfunction, and abnormal clotting profiles that were observed among patients with severe infection. Rapid diagnosis with the use of reverse-transcription polymerase chain reaction and monoclonal antibody-based immunofluorescent assay were of great clinical value in the management of the outbreak. The experience of the H5N1 outbreak in Hong Kong underscores the importance of continuous surveillance of influenza virus strains in humans and in other animal species.