ENHANCEMENT OF SPIKE AND WAVE DISCHARGES BY GABAMIMETIC DRUGS IN RATS WITH SPONTANEOUS PETIT-MAL-LIKE EPILEPSY
ENHANCEMENT OF SPIKE AND WAVE DISCHARGES BY GABAMIMETIC DRUGS IN RATS WITH SPONTANEOUS PETIT-MAL-LIKE EPILEPSY
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DOI：
10.1016/0304-3940(84)90226-x
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发表时间：
1984-01-01
影响因子：
2.5
通讯作者：
WARTER, JM
中科院分区：
文献类型：
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作者：
VERGNES, M;MARESCAUX, C;WARTER, JM
某些Wistar大鼠表现出类似于人类小发作缺失的遗传决定性癫痫发作。蝇蕈醇，THIP [4，5，6，7-四氢异恶唑（5，4-c）吡啶-3-醇]和L-巴氯芬，GABA受体激动剂，和γ-乙烯基GABA（GVG）是GABA降解的抑制剂，能以剂量依赖的方式延长自发性癫痫样发作的持续时间。这些发现提出了问题，GABA能神经传递的作用，发生这种类型的自发尖峰和波放电。
Certain Wistar rats present genetically determined seizures similar to human petit-mal absences. Muscimol, THIP [4,5,6,7-tetrahydroisoxazole (5,4-c)pyridin-3-ol] and L-baclofen, agonists of GABA receptors, and .gamma.-vinyl GABA (GVG), an inhibitor of GABA degradation, enhanced the duration of spontaneous petit-mal-like seizures in a dose-dependent fashion. These findings raise questions as to the role of GABAergic neurotransmission in the occurrence of this type of spontaneous spike and wave discharges.