Effect of sleep stage on interictal high-frequency oscillations recorded from depth macroelectrodes in patients with focal epilepsy
Effect of sleep stage on interictal high-frequency oscillations recorded from depth macroelectrodes in patients with focal epilepsy
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DOI：
10.1111/j.1528-1167.2008.01784.x
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发表时间：
2009-04-01
期刊：
影响因子：
5.6
通讯作者：
Gotman, Jean
中科院分区：
文献类型：
--
作者：
Bagshaw, Andrew P.;Jacobs, Julia;Gotman, Jean
目的 研究睡眠阶段对局灶性癫痫患者深度大电极记录的高频振荡 (HFO) 特性的影响。从 9 名患者以 2 kHz 记录的立体脑电图 (SEEG) 数据中识别出 10 分钟清醒期 (W)、1-2 期非快速眼动睡眠 (N1-N2)、3 期非快速眼动睡眠 (N3) 和快速眼动睡眠 (R)。计算了尖峰、波纹 (> 80 Hz) 和快速波纹 (> 250 Hz) 的速率，以及 HFO 持续时间、尖峰-HFO 重叠程度、尖峰内部和外部以及癫痫发作区 (SOZ) 内部和外部的 HFO 速率。在 9 名患者中观察到波纹，在 8 名患者中观察到快速波纹。 9 名患者中的 5 名在 N1-N2 中峰值率最高，9 名患者中的 4 名在 N3 中最高，而 9 名患者中的 4 名在 N1-N2 中最高，在 9 名患者中 4 名在 N3 中最高，在 9 名患者中 1 名在 W 中最高。 8 名患者中有 4 名在 N1-N2 中快速纹波率最高，8 名患者中有 4 名在 N3 中快速纹波率最高。 HFO 特性随睡眠阶段发生显着变化，但绝对影响很小。 SOZ 内部和外部的 HFO 速率差异在除 R 之外的所有阶段都非常显着 (p < 0.000001)，对于快速波动，在 W 中仅略微显着 (p = 0.018)。从深度宏电极记录的 HFO 速率在非快速眼动睡眠中最高。 HFO 特性在 N1-N2 和 N3 阶段相似，表明不需要进行准确的睡眠分期。 HFO 的空间特异性，特别是快速波动，受到睡眠阶段的影响，这表明排除快速眼动睡眠和清醒状态的记录提供了更可靠的 SOZ 指标。
To investigate the effect of sleep stage on the properties of high-frequency oscillations (HFOs) recorded from depth macroelectrodes in patients with focal epilepsy.Ten-minute epochs of wakefulness (W), stage 1-2 non-REM (N1-N2), stage 3 non-REM (N3) and REM sleep (R) were identified from stereo-electroencephalography (SEEG) data recorded at 2 kHz in nine patients. Rates of spikes, ripples (> 80 Hz), and fast ripples (> 250 Hz) were calculated, as were HFO durations, degree of spike-HFO overlap, HFO rates inside and outside of spikes, and inside and outside of the seizure-onset zone (SOZ).Ripples were observed in nine patients and fast ripples in eight. Spike rate was highest in N1-N2 in 5 of 9 patients, and in N3 in 4 of 9 patients, whereas ripple rate was highest in N1-N2 in 4 of 9 patients, in N3 in 4 of 9 patients, and in W in 1 of 9 patients. Fast ripple rate was highest in N1-N2 in 4 of 8 patients, and in N3 in 4 of 8 patients. HFO properties changed significantly with sleep stage, although the absolute effects were small. The difference in HFO rates inside and outside of the SOZ was highly significant (p < 0.000001) in all stages except for R and, for fast ripples, only marginally significant (p = 0.018) in W.Rates of HFOs recorded from depth macroelectrodes are highest in non-REM sleep. HFO properties were similar in stages N1-N2 and N3, suggesting that accurate sleep staging is not necessary. The spatial specificity of HFO, particularly fast ripples, was affected by sleep stage, suggesting that recordings excluding REM sleep and wakefulness provide a more reliable indicator of the SOZ.