The Effects of Serum Testosterone, Estradiol, and Sex Hormone Binding Globulin Levels on Fracture Risk in Older Men
The Effects of Serum Testosterone, Estradiol, and Sex Hormone Binding Globulin Levels on Fracture Risk in Older Men
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DOI：
10.1210/jc.2009-0206
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发表时间：
2009-09-01
影响因子：
5.8
通讯作者：
Orwoll, Eric S.
中科院分区：
文献类型：
--
作者：
LeBlanc, Erin S.;Nielson, Carrie M.;Orwoll, Eric S.
背景：性类固醇与骨折之间的关系尚不清楚。目的：本研究的目的是研究非椎体骨折风险与生物有效雌二醇（bioE2）、生物有效睾酮（bioT）和SHBG之间的关系。设计：这是一项病例队列研究。背景：男性骨质疏松性骨折研究（MrOS）在5995名65岁或以上的美国社区男性中进行。参与者：参与者包括1436名随机选择的白人男性和446名少数民族以及所有发生髋关节和其他非椎体骨折的人。主要观察指标：基线睾酮和雌二醇采用质谱（MS）测定，SHBG采用RIA测定。结果：最低bioE2 （59.1 nM）的男性发生所有非椎体骨折的风险更高[校正风险比（HR）[95%可信区间]分别为1.5（1.2-1.9）和1.4(1.1-21.8)]。生理生化值最低的男性(
Context: The relationship between sex steroids and fracture is poorly understood.Objective: The objective of the study was to examine associations between nonvertebral fracture risk and bioavailable estradiol (bioE2), bioavailable testosterone (bioT), and SHBG.Design: This was a case-cohort study.Setting: The Osteoporotic Fractures in Men Study (MrOS) was conducted in a prospective U. S. cohort in 5995 community-dwelling men 65 yr old or older.Participants: Participants included a subcohort of 1436 randomly chosen white men plus all 446 minorities and all those with incident hip and other nonvertebral fractures.Main Outcome Measures: Baseline testosterone and estradiol were measured by mass spectrometry (MS) and SHBG by RIA.Results: Men with the lowest bioE2 ( 59.1 nM) had greater risk of all nonvertebral fractures [adjusted hazard ratio (HR) [95% confidence interval]: 1.5 (1.2-1.9) and 1.4 (1.1-21.8), respectively]. Men with the lowest bioT (