The Eurasian Heartland: A continental perspective on Y-chromosome diversity
The Eurasian Heartland: A continental perspective on Y-chromosome diversity
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DOI：
10.1073/pnas.171305098
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发表时间：
2001-08-28
影响因子：
11.1
通讯作者：
Bodmer, WF
中科院分区：
文献类型：
--
作者：
Wells, RS;Yuldasheva, N;Bodmer, WF
人类Y染色体的非重组部分已被证明是研究人口历史的一个有价值的工具。维持特定地理区域的扩展单倍型特征，尽管广泛的混合，允许复杂的人口事件被解构。在这项研究中，我们报告了来自49个欧亚人群的1935名男性的23个y染色体双等位基因多态性单倍型的频率，特别关注中亚。这些单倍型揭示了历史迁徙的痕迹，并提供了解剖学上现代人类在欧亚大陆上最早定居模式的见解。中亚是遗传多样性的重要储存库，也是至少三次主要移民潮的源头，这些移民潮最终进入了欧洲、美洲和印度。遗传结果在欧亚语言模式的背景下得到解释。
The nonrecombining portion of the human Y chromosome has proven to be a valuable tool for the study of population history. The maintenance of extended haplotypes characteristic of particular geographic regions, despite extensive admixture, allows complex demographic events to be deconstructed. In this study we report the frequencies of 23 Y-chromosome biallelic polymorphism haplotypes in 1,935 men from 49 Eurasian populations, with a particular focus on Central Asia. These haplotypes reveal traces of historical migrations, and provide an insight into the earliest patterns of settlement of anatomically modern humans on the Eurasian continent. Central Asia is revealed to be an important reservoir of genetic diversity, and the source of at least three major waves of migration leading into Europe, the Americas, and India. The genetic results are interpreted in the context of Eurasian linguistic patterns.