Immunohistochemical study of adhesion molecules in liver inflammation
Immunohistochemical study of adhesion molecules in liver inflammation
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DOI：
10.1002/hep.1840120110
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发表时间：
1990-07
期刊：
影响因子：
13.5
通讯作者：
R. Volpes;J. J. van den Oord-J.;V. Desmet
中科院分区：
文献类型：
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作者：
R. Volpes;J. J. van den Oord-J.;V. Desmet
使用单克隆抗体和原位免疫组织化学，我们研究了“辅助”粘附分子（即，细胞间粘附分子-1和白细胞功能相关抗原-3）在114例各种炎症性肝病肝活检标本和12例无炎症的对照肝活检标本中的表达。将这些粘附分子的分布分别与其天然配体淋巴细胞功能相关抗原-1和分化抗原簇-2在炎症细胞上的存在进行比较。
Using monoclonal antibodies and in situ immunohistochemistry, we studied the distribution of “accessory” adhesion molecules (i.e., intercellular adhesion molecule‐1 and leukocyte function–associated antigen‐3) in 114 liver biopsy specimens with various inflammatory liver diseases and in 12 control liver biopsy samples without inflammation. The distribution of these adhesion molecules was compared with the presence on inflammatory cells of their natural ligands, lymphocyte function–associated antigen‐1 and cluster of differentiation antigen‐2, respectively.