Comparative genomics of the oxidative phosphorylation system in fungi
Comparative genomics of the oxidative phosphorylation system in fungi
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DOI：
10.1016/j.fgb.2008.06.005
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发表时间：
2008-09-01
影响因子：
3
通讯作者：
Pisabarro, Antonio G.
中科院分区：
文献类型：
--
作者：
Lavin, Jose L.;Oguiza, Jose A.;Pisabarro, Antonio G.
在这项研究中，我们对真菌的线粒体和核基因组进行了计算机分析，以确定氧化磷酸化（OXPHOS）蛋白质组，这是一套完整的蛋白质，在线粒体中执行OXPHOS。OXPHOS蛋白的存在已被调查的27个核和52个线粒体基因组的真菌。比较基因组学揭示了每个真菌门内的OXPHOS系统的高度保守性，以及真菌门的OXPHOS蛋白质组之间的显著差异。最显着的差异涉及复合物I和V.的情况下，复合物I先前已被描述在各种物种的子囊菌门和微孢子虫，和NDUFB 4和NDUBM辅助亚基的复合物I似乎是特定的真菌属于亚门盘菌亚门。此外，复合体V必需亚基ATP 14似乎是子囊菌门的两个亚门：盘菌亚门和盘菌亚门的特异性。(C)2008年爱思唯尔公司All rights reserved.
In this study, we have Carried out an in silico analysis of the available mitochondrial and nuclear genomes of fungi in order to identify the oxidative phosphorylation (OXPHOS) Proteome, the complete set of proteins that perform the OXPHOS in mitochondria. The presence of OXPHOS proteins has been investigated in 27 nuclear and 52 mitochoncrial genomes of fungi. Comparative genomics reveals a high conservation of the OXPHOS system within each fungal phyla, and notable differences between the OXPHOS proteomes of the fungal phyla. The most striking differences concerned Complexes I and V. The absence of Complex I has been previously described in various species of Ascomycota and Microsporidia, and the NDUFB4 and NURM accessory subunits of Complex I appear to be specific of fungi belonging to the sub-phylum Pezizomycotina. In addition, the Complex V essential subunit ATP14 appears to be specific of two subphyla of Ascomycota: the Saccharomycotina and Pezizomycotina. (C) 2008 Elsevier Inc. All rights reserved.