The effect of smoking and eating habits on DNA damage in Indian population as measured in the Comet assay
The effect of smoking and eating habits on DNA damage in Indian population as measured in the Comet assay
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DOI：
10.1016/s0027-5107(00)00171-8
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发表时间：
2001-03-01
影响因子：
2.3
通讯作者：
Seth, PK
中科院分区：
文献类型：
--
作者：
Dhawan, A;Mathur, N;Seth, PK
这项研究的目的是评估正常健康印度人群的 DNA 损伤状况。这项研究的62名男性志愿者分别属于吸烟、不吸烟、素食和非素食类别，受过良好教育，年龄在23岁至57岁之间。数据显示，吸烟者与非吸烟者以及素食者与非素食者之间的 DNA 损伤程度存在显着差异。根据吸烟程度的不同，不同吸烟者群体之间也观察到显着差异。还观察到 DNA 损伤存在年龄依赖性效应。这项初步研究首次揭示了正常印度人群 DNA 损伤程度的差异，具体取决于他们的饮食、吸烟习惯以及年龄。 (C) 2001 Elsevier Science B.V. 保留所有权利。
This study was undertaken with the aim of assessing the status of DNA damage in a normal healthy Indian population. The 62 male volunteers in this study belonged to the smoking, non-smoking, vegetarian and non-vegetarian categories, were well educated and aged between 23 and 57 years. The data revealed significant differences in the extent of DNA damage in the smokers versus non-smokers as well as between the vegetarians and non-vegetarians. A significant difference was also observed amongst the different groups of smokers depending on the extent of smoking. An age-dependent effect in DNA damage was also observed. This preliminary study has, for the first time, revealed differences in the extent of DNA damage in the normal Indian population depending on their eating and smoking habits as well as age. (C) 2001 Elsevier Science B.V. All rights reserved.