Prostaglandin E2 and T cells: friends or foes?
Prostaglandin E2 and T cells: friends or foes?
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DOI：
10.1038/icb.2011.75
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发表时间：
2012-07
影响因子：
4
通讯作者：
Cuesta, Natalia
中科院分区：
文献类型：
--
作者：
Sreeramkumar, Vinatha;Fresno, Manuel;Cuesta, Natalia
我们对炎症、感染和自身免疫过程中T细胞反应的不同调节所涉及的关键因素的了解是设计有效的免疫疾病治疗策略的基础。关于这一点，自20世纪70年代以来，脂类介体前列腺素E2(PGE2)在T细胞免疫中的抑制作用已被证实。随后的研究证实了微摩尔浓度的PGE2在T细胞的激活、增殖、分化和迁移中的抑制作用。然而，在过去的十年里，这方面发生了一场革命，因为纳米分子浓度的PGE2被证明可以增强Th1和Th17的反应，并有助于T细胞的增殖。对PGE2在其他细胞类型中浓度特异性效应的了解，PGE2受体各亚型缺陷小鼠的发育，以及EP受体介导的信号通路的描绘，加深了我们对PGE2作为免疫刺激剂的理解。PGE2调节T细胞活化和分化的多种功能，这些作用取决于细胞的微环境、细胞的成熟和激活状态、所涉及的EP受体的类型、PGE2的局部浓度以及是稳态还是炎症情况。在这篇综述中，我们划分了PGE2与T淋巴细胞这一复杂关系的不同方面。鉴于这种分子在T细胞激活中的重要性，我们还讨论了使用EP受体拮抗剂作为一些免疫疾病的潜在治疗方法的可能性。
Our understanding of the key players involved in the differential regulation of T-cell responses during inflammation, infection and auto-immunity is fundamental for designing efficient therapeutic strategies against immune diseases. With respect to this, the inhibitory role of the lipid mediator prostaglandin E2 (PGE2) in T-cell immunity has been documented since the 1970s. Studies that ensued investigating the underlying mechanisms substantiated the suppressive function of micromolar concentrations of PGE2 in T-cell activation, proliferation, differentiation and migration. However, the past decade has seen a revolution in this perspective, since nanomolar concentrations of PGE2 have been shown to potentiate Th1 and Th17 responses and aid in T-cell proliferation. The understanding of concentration-specific effects of PGE2 in other cell types, the development of mice deficient in each subtype of the PGE2 receptors (EP receptors) and the delineation of signalling pathways mediated by the EP receptors have enhanced our understanding of PGE2 as an immune-stimulator. PGE2 regulates a multitude of functions in T-cell activation and differentiation and these effects vary depending on the micro-environment of the cell, maturation and activation state of the cell, type of EP receptor involved, local concentration of PGE2 and whether it is a homeostatic or inflammatory scenario. In this review, we compartmentalize the various aspects of this complex relationship of PGE2 with T lymphocytes. Given the importance of this molecule in T-cell activation, we also address the possibility of using EP receptor antagonism as a potential therapeutic approach for some immune disorders.
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影响因子：
20.3
作者：
Chizzolini, Carlo;Chicheportiche, Rachel;Dayer, Jean-Michel
通讯作者：
Dayer, Jean-Michel
影响因子：
4.8
作者：
Caristi, S;Piraino, G;Teti, D
通讯作者：
Teti, D
影响因子：
11.2
作者：
Chemnitz, JM;Driesen, J;Schultze, JL
通讯作者：
Schultze, JL
DOI：
10.1016/0192-0561(84)90029-8
发表时间：
1984-01-01
期刊：
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY
影响因子：
--
作者：
CAHILL, J;HOPPER, KE
通讯作者：
HOPPER, KE
影响因子：
4.3
作者：
BASTIN, B;PAYET, MD;DUPUIS, G
通讯作者：
DUPUIS, G