Ultrasound-Mediated Remotely Controlled Nanovaccine Delivery for Tumor Vaccination and Individualized Cancer Immunotherapy
Ultrasound-Mediated Remotely Controlled Nanovaccine Delivery for Tumor Vaccination and Individualized Cancer Immunotherapy
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超声介导的远程控制纳米疫苗递送用于肿瘤疫苗接种和个体化癌症免疫治疗
DOI：
10.1021/acs.nanolett.0c03646
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发表时间：
2021-02-01
期刊：
影响因子：
10.8
通讯作者：
Liu, Zhuang
中科院分区：
文献类型：
--
作者：
Meng, Zhouqi;Zhang, Yaojia;Liu, Zhuang
疫苗是现代医学中对抗多种疾病的最重要武器之一。为了达到最佳的疫苗接种效果，经常需要重复注射疫苗，这将大大降低患者的舒适度。本文中，装载有纳米疫苗的超声响应性自愈水凝胶系统被设计用于远程控制肿瘤疫苗释放和个体化癌症免疫治疗。这种凝胶可以在超声波处理下转变为溶胶状态，从而允许纳米疫苗的爆发释放，然后自我修复为凝胶。对于单次皮下注射纳米疫苗负载凝胶和多次超声治疗的小鼠，重复释放的纳米疫苗可以引发抗肿瘤免疫应答，结合免疫检查点阻断可以有效抑制已建立的肿瘤，并基于我们的个性化纳米疫苗系统预防术后肿瘤转移和复发。这项工作提出了一种易于操作的策略，以实现针对癌症和潜在的其他类型疾病的疫苗的可控和持久的递送。
Vaccines are one of utmost important weapons in modern medicine to fight a wide range of diseases. To achieve optimal vaccination effects, repeated injections of vaccines are often required, which would largely decrease patient comfort. Herein, an ultrasound-responsive self-healing hydrogel system loaded with nanovaccines is designed for remotely controlled tumor vaccine release and individualized cancer immunotherapy. The gel could be transformed into sol status in response to ultrasound treatment, allowing a burst release of nanovaccines, and self-healed to gel afterward. For mice with a single subcutaneous injection of nanovaccine-loaded gel and multiple ultrasound treatments, repeatedly released nanovaccines could elicit antitumor immune responses, which in combination with immune checkpoint blockade could effectively inhibit established tumors, and prevent postoperative tumor metastases and recurrence based on our personalized nanovaccine system. This work presents an easy-to-operate strategy to realize controllable and durable delivery of vaccines against cancer and potentially other types of diseases.