High levels of Lp(a) with a small apo(a) isoform are associated with coronary artery disease in African American and white men
High levels of Lp(a) with a small apo(a) isoform are associated with coronary artery disease in African American and white men
复制标题
DOI：
10.1161/01.atv.20.12.2619
复制
发表时间：
2000-12-01
影响因子：
8.7
通讯作者：
Berglund, L
中科院分区：
文献类型：
--
作者：
Paultre, F;Pearson, TA;Berglund, L
脂蛋白（a）[Lp（a）]水平升高和载脂蛋白（a）[apo（a）]小亚型的存在与白人冠状动脉疾病（CAD）相关，但与非裔美国人无关。由于不同apo（a）大小的Lp（a）水平分布存在明显的种族/民族差异，我们检验了apo（a）亚型大小决定Lp（a）与CAD之间相关性的假设。我们在576名白色和非洲裔美国男性和女性中将Lp（a）水平、载脂蛋白（a）亚型以及与不同载脂蛋白（a）亚型相关的Lp（a）水平与CAD（大于或等于50%狭窄）的存在相关联。只有在白色男性中，冠心病患者的Lp（a）水平显著高于非冠心病患者（分别为28.4和16.5 mg/dL; P=0.004），并且只有在该组中存在小的载脂蛋白（a）亚型（
Elevated levels of lipoprotein(a) [Lp(a)] and the presence of small isoforms of apolipoprotein(a) [apo(a)] have been associated with coronary artery disease (CAD) in whites but not in African Americans. Because of marked race/ethnicity differences in the distribution of Lp(a) levels across apo(a) sizes, we tested the hypothesis that apo(a) isoform size determines the association between Lp(a) and CAD. We related Lp(a) levels, apo(a) isoforms, and the levels of Lp(a) associated with different apo(a) isoforms to the presence of CAD (greater than or equal to 50% stenosis) in 576 white and African American men and women. Only in white men were Lp(a) levels significantly higher among patients with CAD than in those without CAD (28.4 versus 16.5 mg/dL, respectively; P=0.004), and only in this group was the presence of small apo(a) isoforms (